{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:48Z","timestamp":1790175108158,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["124156934914"],"award-info":[{"award-number":["124156934914"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008745","name":"Universidad Aut\u00f3noma de Bucaramanga","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with haemophilia may have lower levels of bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) compared with the general population. Moreover, haemophilic patients have increased risk factors for low bone mineral density (<jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content>) such as arthropathy and resulting immobility, increasing their risk for osteoporosis and fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the prevalence of <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content> and associated risk factors among a group of Colombian haemophilic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2010control study, 90 patients with haemophilia A and B, over the age of five, were recruited. Controls were healthy participants matched by age, gender, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), socioeconomic status, and race. All participants underwent dual energy X\u2010ray absorptiometry (<jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content>) and the Global Physical Activity Questionnaire. Blood tests were collected to evaluate <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content> determinants in cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> was lower in cases than in the control group. <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of femoral necks was 0.907\u00a0g\/cm<jats:sup>2<\/jats:sup> in cases vs. 1.020\u00a0g\/cm<jats:sup>2<\/jats:sup> in controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.019), and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> of hips 0.930\u00a0g\/cm<jats:sup>2<\/jats:sup> in cases vs. 1030\u00a0g\/cm<jats:sup>2<\/jats:sup> in controls (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.019). The greater the severity of haemophilia, the lower <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in spine, femoral neck, and hips. Elevated C\u2010protein levels were found in 44.1% of patients with <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content> and 14.8% with normal <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.003). The study found an adjusted prevalence ratio of 2.11, indicating that haemophilic patients are two times more likely to have <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>95%\u00a0=\u00a01.43\u20103.11 <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results from the present study showed that haemophilia was associated with a higher frequency of <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content>. Severity of haemophilia, haemophilic arthropathy, and elevated C\u2010reactive protein levels was directly associated with <jats:styled-content style=\"fixed-case\">LBMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13516","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T16:06:35Z","timestamp":1528992395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Low bone mineral density and associated factors in patients with haemophilia in Colombia"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9876-222X","authenticated-orcid":false,"given":"C. L.","family":"Sossa Melo","sequence":"first","affiliation":[{"name":"Division of Hematology and Hematopoietic Stem Cell Transplantation Department of Internal Medicine School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"},{"name":"Hematology and Hematopoietic Stem Cell Transplantation Unit Clinica Carlos Ardila Lulle  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. A.","family":"Wandurraga","sequence":"additional","affiliation":[{"name":"Department of Endocrinology School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematopoietic Stem Cell Transplantation Department of Internal Medicine School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"},{"name":"Hematology and Hematopoietic Stem Cell Transplantation Unit Clinica Carlos Ardila Lulle  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. I.","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematopoietic Stem Cell Transplantation Department of Internal Medicine School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"},{"name":"Hematology and Hematopoietic Stem Cell Transplantation Unit Clinica Carlos Ardila Lulle  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Salazar","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematopoietic Stem Cell Transplantation Department of Internal Medicine School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"},{"name":"Hematology and Hematopoietic Stem Cell Transplantation Unit Clinica Carlos Ardila Lulle  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Department of Public Health School of Medicine Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Luna\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Research Department Universidad Autonoma de Bucaramanga  Bucaramanga Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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