{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:34:37Z","timestamp":1788449677117,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009431","name":"Baxalta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"\n Introduction<\/jats:title>\n \n Recurrent joint bleeding is the hallmark of haemophilia. Synovial hypertrophy observed with Magnetic Resonance Imaging (\n MRI<\/jats:styled-content>\n ) is associated with an increased risk of future joint bleeding.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n The aim of this study was to investigate whether point\u2010of\u2010care ultrasound (\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n ) is an accurate alternative for\n MRI<\/jats:styled-content>\n for the detection of early joint changes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this single centre diagnostic accuracy study, bilateral knees and ankles of haemophilia patients with no or minimal arthropathy on X\u2010rays were scanned using\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n and 3 Tesla\n MRI<\/jats:styled-content>\n .\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n was performed by 1 medical doctor, blinded for\n MRI<\/jats:styled-content>\n , according to the \u201cHaemophilia Early Arthropathy Detection with Ultrasound\u201d (\n HEAD<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n ) protocol.\n MRI<\/jats:styled-content>\n s were independently scored by 2 radiologists, blinded for clinical data and ultrasound results. Diagnostic accuracy parameters were calculated with 95% confidence intervals (\n CI<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Knees and ankles of 24 haemophilia patients (96 joints), aged 18\u201034, were studied. Synovial hypertrophy on\n MRI<\/jats:styled-content>\n was observed in 20% of joints.\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n for synovial tissue was correct (overall accuracy) in 97% (\n CI<\/jats:styled-content>\n : 91\u201099) with a positive predictive value of 94% (\n CI<\/jats:styled-content>\n : 73\u2010100) and a negative predictive value of 97% (\n CI<\/jats:styled-content>\n : 91\u2010100). The overall accuracy of\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n for cartilage abnormalities was 91% (\n CI<\/jats:styled-content>\n : 83\u201096) and for bone surface irregularities 97% (\n CI<\/jats:styled-content>\n : 91\u201099).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n could accurately assess synovial hypertrophy, bone surface irregularities and cartilage abnormalities in haemophilia patients with limited joint disease. As\n POC<\/jats:styled-content>\n \u2010\n US<\/jats:styled-content>\n is an accurate and available alternative for\n MRI<\/jats:styled-content>\n , it can be used for routine evaluation of early joint changes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/hae.13524","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T07:35:22Z","timestamp":1527060922000},"page":"971-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Diagnostic accuracy of point\u2010of\u2010care ultrasound for evaluation of early blood\u2010induced joint changes: Comparison with\n MRI<\/scp>"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4970-8555","authenticated-orcid":false,"given":"W.","family":"Foppen","sequence":"first","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. C.","family":"van der Schaaf","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J. A.","family":"Beek","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. P. T. M.","family":"Mali","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-6613","authenticated-orcid":false,"given":"K.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Utrecht The Netherlands"},{"name":"Van Creveldkliniek Department of Hematology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Clotting factor concentrates given to prevent bleeding and bleeding\u2010related complications in people with hemophilia A or B (Review)","volume":"9","author":"Iorio A","year":"2011","journal-title":"Cochrane Database Syst 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