{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:29:13Z","timestamp":1790065753181,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T00:00:00Z","timestamp":1530230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The thrombin generation (\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      ) assay can assess individual clotting potential. The thrombin generation potential is correlated with the patient's bleeding phenotype and varies from one patient to the other for the same degree of factor\n                      <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      deficiency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To define in vitro for individual haemophilic patients the target factor\n                      <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      level required to normalize their\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>\n                      Plasmas from 20 haemophilic patients were spiked with increasing levels of the deficient coagulation factor and\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      parameters were measured. The relationships between factor levels and\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      parameters were determined by linear regression. The normal range of thrombin generation was defined in 39 healthy male volunteers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Despite inter\u2010individual heterogeneity in basal\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      and responses to spiking, a linear relationship was found between factor\n                      <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      levels and\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      parameters for individual patients. Based on the individual responses of patient plasmas to spiking, it is possible to define in vitro the target factor\n                      <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      levels needed to normalize the\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      parameters. For both haemophilic A and haemophilic B patients, significant correlations were found between basal peak values and their correction slopes. The correction slope was steeper in haemophilic B patients, so the factor\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      level needed to normalize the\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      parameters was lower than for haemophilic A patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      assay could be used to determine in vitro the patient\u2010specific factor\n                      <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>\n                      or\n                      <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content>\n                      level to be reached to effectively normalize their\n                      <jats:styled-content style=\"fixed-case\">TG<\/jats:styled-content>\n                      . These in vitro results should be confirmed by ex\u2010vivo studies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.13539","type":"journal-article","created":{"date-parts":[[2018,6,29]],"date-time":"2018-06-29T09:02:45Z","timestamp":1530262965000},"page":"995-1001","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prediction of individual factor\n                    <scp>VIII<\/scp>\n                    or\n                    <scp>IX<\/scp>\n                    level for the correction of thrombin generation in haemophilic patients"],"prefix":"10.1111","volume":"24","author":[{"given":"P.","family":"Chelle","sequence":"first","affiliation":[{"name":"Mines saint\u2010Etienne Univ Lyon Univ Jean Monnet INSERM Centre CIS  Saint Etienne France"},{"name":"INSERM U1059 SAINBIOSE Univ Lyon  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Montmartin","sequence":"additional","affiliation":[{"name":"INSERM U1059 SAINBIOSE Univ Lyon  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piot","sequence":"additional","affiliation":[{"name":"INSERM U1059 SAINBIOSE Univ Lyon  Saint Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ardillon","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9matologie\u2010H\u00e9mostase CHU Trousseau  Tours Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Wibaut","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d'H\u00e9mostase Clinique Institut C\u0153ur Poumon Haemophilia Treatment Centre CHRU Lille  Lille 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