{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:07:41Z","timestamp":1762459661648,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T00:00:00Z","timestamp":1533686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Haemophilic children are prone to low bone mass accrual.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess bone properties in haemophilic children, using peripheral quantitative computed tomography (pQCT) and to correlate findings with clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects\/Methods<\/jats:title><jats:p>Peripheral quantitative computed tomography scan of both radii and tibiae were performed in 31 haemophilic A children (severe 24, mean age 11.2\u00a0years). Seven subjects had a history of inhibitors. Five children had an upper extremity target\u2010joint and 12 had at least one lower extremity target\u2010joint. The following parameters were measured: trabecular, total and cortical bone density and content (TBD, ToBD, CBD, TbC, CC), strength\u2010stress index (SSI), and tibial cross\u2010sectional area (CA), outer and inner bone contour length (PERI, ENDO) and cortical thickness (CTHC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean right radius TBD was significantly higher than the left one (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015). In subjects with arm target\u2010joint, radius TBD was significantly lower in the target than in non\u2010target arm (186.6\u00a0\u00b1\u00a060.4 vs 218.6\u00a0\u00b1\u00a039.8, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.032). Left arm target\u2010joint subjects had significantly lower left radius TBD in comparison to subjects without arm target\u2010joint (155.4\u00a0\u00b1\u00a050.3 vs 215.7\u00a0\u00b1\u00a037.9, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.019). There were no similar differences in leg target\u2010joint. Bone quality and geometry parameters in cortical compartment were significantly lesser in inhibitor group, with statistically significant side\u2010to\u2010side differences for legs and arms and left side predominance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In children with haemophilia A and a history of target\u2010joint and\/or FVIII inhibitor, abnormalities may occur in the long bones as were revealed by pQCT, where low trabecular density and weak cortical bone quality in upper and lower extremities, respectively, were confirmed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13591","type":"journal-article","created":{"date-parts":[[2018,8,8]],"date-time":"2018-08-08T09:09:57Z","timestamp":1533719397000},"page":"800-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of target joint and FVIII inhibitor \u03bfn bone properties in children with haemophilia A: A peripheral quantitative computed tomography study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-902X","authenticated-orcid":false,"given":"Panagiota","family":"Xafaki","sequence":"first","affiliation":[{"name":"Haemophilia Centre\u2010 Haemostasis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexia","family":"Balanika","sequence":"additional","affiliation":[{"name":"Second Radiology Department \u201cAttikon\u201d University Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-0597","authenticated-orcid":false,"given":"Helen","family":"Pergantou","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\u2010 Haemostasis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olympia","family":"Papakonstantinou","sequence":"additional","affiliation":[{"name":"Second Radiology Department \u201cAttikon\u201d University Hospital  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Platokouki","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\u2010 Haemostasis Unit \u201cAghia Sophia\u201d Children's Hospital  Athens 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