{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:50:30Z","timestamp":1768683030495,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Patrizia Guarraci of Bayer Healthcare"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In older people, multiple chronic ailments lead to the intake of multiple medications (polypharmacy) that carry a number of negative consequences (adverse events, prescription and intake errors, poor adherence, higher mortality). Because ageing patients with haemophilia (PWHs) may be particularly at risk due to their pre\u2010existing multiple comorbidities (arthropathy, liver disease), we chose to analyse the pattern of chronic drug intake in a cohort of PWHs aged 60\u00a0years or more.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>S\u00a0+\u00a0PHERA is a multicentre observational study, with the broad goal to evaluate prospectively the health status and medication intake in 102 older patients with severe haemophilia A or B compared with 204 age\u2010 and residence\u2010matched controls chosen randomly from the same general practices of PWHs. The rate of potential drug\u2010drug interactions (PDDI) was evaluated as a proxy of prescription appropriateness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After excluding replacement therapies and antiviral drugs, PWHs took in average less daily drugs than controls (2.4\u00a0\u00b1\u00a02.5 vs 3.0\u00a0\u00b1\u00a02.4) and had a lower rate of polypharmacy. Moreover, their prevalence of PDDI was lower (16.7% vs 27%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of polypharmacy and the appropriateness of medications other than those for haemophilia and related comorbidities are acceptable in Italian PWHs, and better than those in their age peers without haemophilia, perhaps owing to drug tailoring and deprescribing by the specialized haemophilia centres at the time of regular visits. However, the PWHs investigated herewith were relatively young and the rate of polypharmacy and related PDDIs may become more prominent and crucial when older ages are reached, suggesting the need of continuous surveillance on prescribed drugs and the risk of drug\u2010drug interactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13595","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T09:21:34Z","timestamp":1534411294000},"page":"726-732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age\u2010matched controls"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1915-3897","authenticated-orcid":false,"given":"Pier Mannuccio","family":"Mannucci","sequence":"first","affiliation":[{"name":"Scientific Direction IRCCS Ca\u2019 Granda Maggiore Hospital Foundation University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Nobili","sequence":"additional","affiliation":[{"name":"Neuroscience Department IRCCS Istituto di Ricerche Farmacologiche Mario Negri  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Marchesini","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\u2010 SC Vascular and Emergency Department University of Perugia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Oliovecchio","sequence":"additional","affiliation":[{"name":"Haemophilia Centre\u2010 SC Vascular and Emergency Department University of Perugia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Cortesi","sequence":"additional","affiliation":[{"name":"Neuroscience Department IRCCS Istituto di Ricerche Farmacologiche Mario Negri  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Coppola","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Coagulation Disorders Federico II University Hospital  Naples Italy"},{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Santagostino","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Radossi","sequence":"additional","affiliation":[{"name":"Transfusion Service Haemophilia Centre and Haematology Castelfranco Veneto Hospital  Castelfranco Veneto Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Castaman","sequence":"additional","affiliation":[{"name":"Center for Bleeding Disorders and Coagulation Department of Oncology Careggi University Hospital  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lelia","family":"Valdr\u00e8","sequence":"additional","affiliation":[{"name":"Unit of Angiology and Coagulation Disorders S. Orsola\u2010Malpighi University Hospital  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-447X","authenticated-orcid":false,"given":"Cristina","family":"Santoro","sequence":"additional","affiliation":[{"name":"Haematology Department of Cellular Biotechnologies and Hematology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-6334","authenticated-orcid":false,"given":"Annarita","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosimo","family":"Ettorre","sequence":"additional","affiliation":[{"name":"Haemophilia and Thrombosis Center Policlinico Giovanni XXIII  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezio","family":"Zanon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Vascular Medicine Unit University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barillari","sequence":"additional","affiliation":[{"name":"Center for Haemorrhagic and Thrombotic Disorders Udine General and University Hospital  Udine Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Cantori","sequence":"additional","affiliation":[{"name":"Haemophilia Center Regional Reference Center for Inherited Bleeding and Thrombophilic Disorders Civil Hospital  Macerata Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Maria","family":"Caimi","sequence":"additional","affiliation":[{"name":"A De Gasperis Cardiovascular Department Niguarda Ca\u2019 Granda Hospital  Milan 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