{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:21:33Z","timestamp":1775438493014,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Persons with haemophilia (<jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>) experience recurrent joint bleeding which leads from early synovitis to irreversible joint damage. Pain strongly affects patients\u2019 quality of life, as <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> suffer from acute pain associated with haemarthroses and chronic pain due to arthritic and degenerative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate pain issues among <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> and their treaters in Italy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Persons with haemophilia and specialist physicians responded to a survey focused on pain characteristics, assessment, and management by phone call and online, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and nineteen patients (76% severe haemophilia, 61% \u226518\u00a0years) and 44 physicians were involved. Pain was reported by 61% of <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>; among those who did not experience pain, 70% were children on prophylaxis. Patients described pain as chronic (71%), acute (69%) or postoperative (8%), and rated it as severe in 65% of cases. Clinicians reported lower percentages of patients with pain (46%), classified as chronic (58%), acute (33%) or postoperative (21%), half using specific scales. Pain was systematically investigated by treaters according to 36% of patients. Paracetamol was largely the most prescribed first\u2010line pain therapy (89%), as well the most employed analgesic by <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> (51%), who also used non\u2010steroidal anti\u2010inflammatory drugs (24%), cyclo\u2010oxygenase\u20102 inhibitors (21%) or opioids (26%). To manage pain, 61% of clinicians stated to collaborate with other specialists. Physiotherapy was often suggested but less frequently used by <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pain is under\u2010recognized and unsatisfactorily addressed by haemophilia treatment centre (HTC) clinicians, with discrepant management compared to <jats:styled-content style=\"fixed-case\">PWH<\/jats:styled-content> responses. Education in systematic pain assessment and multidisciplinary treatment and development of management guidelines are highly needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13600","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T09:03:18Z","timestamp":1534410198000},"page":"766-773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Pain assessment and management in haemophilia: A survey among Italian patients and specialist physicians"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-6334","authenticated-orcid":false,"given":"Annarita","family":"Tagliaferri","sequence":"first","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-0580","authenticated-orcid":false,"given":"Massimo","family":"Franchini","sequence":"additional","affiliation":[{"name":"Department of Haematology and Transfusion Medicine Carlo Poma Hospital  Mantua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna F.","family":"Rivolta","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Farace","sequence":"additional","affiliation":[{"name":"Italian Federation of Haemophilia Associations (FedEmo)  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Quintavalle","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3697-706X","authenticated-orcid":false,"given":"Antonio","family":"Coppola","sequence":"additional","affiliation":[{"name":"Regional Reference Centre for Inherited Bleeding Disorders University Hospital of Parma  Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the ad hoc Study 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