{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:51:46Z","timestamp":1790175106297,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia is a recessive X\u2010linked inherited bleeding disorder, whose typical symptom is spontaneous intra\u2010articular haemorrhage leading to joint damage, which can be quantified by the Haemophilia Joint Health Score (HJHS). Arthropathy and other characteristics of haemophilic patients may reduce bone mineral density (BMD), increasing the risk for fragility fractures, which also may occur due to bone quality impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate bone quantity by BMD and bone quality by Trabecular Bone Score (TBS), bone strain (BS) and hip structural analysis (HSA) in a haemophilic population, and to relate these parameters to general and specific risk factors for osteoporosis and to HJHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy haemophilic patients \u226518\u00a0years were enrolled. Densitometric derived lumbar spine and femoral BMD with TBS, BS and HSA were performed. Data regarding risk factors for osteoporosis, presence of arthroprosthesis or arthrodesis were collected, and HJHS was calculated. A Z\u2010score \u2264\u22122.0 defined a low bone mass.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, a reduced bone mass was present in 52 patients at the femur and in 38 at the lumbar spine. Lumbar spine BMD, TBS and BS did not correlate with HJHS. HSA bone geometric parameters correlated negatively with HJHS. BMD and HSA correlated with some risk factors for osteoporosis, namely HIV and its therapy, hepatitis C and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haemophilic patients showed a reduced BMD at lumbar spine and\/or femur. Femoral bone density and geometry correlated with HJHS. The microarchitecture of the trabecular vertebral bone seemed to be not influenced by the haemophilic joint damage.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13611","type":"journal-article","created":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T23:58:29Z","timestamp":1538438309000},"page":"980-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Usefulness of bone microarchitectural and geometric DXA\u2010derived parameters in haemophilic patients"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1357-3425","authenticated-orcid":false,"given":"Fabio Massimo","family":"Ulivieri","sequence":"first","affiliation":[{"name":"Nuclear Medicine, Bone Metabolic Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Antonella Angela","family":"Rebagliati","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation University of Milan Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Petruccio","family":"Piodi","sequence":"additional","affiliation":[{"name":"Former: Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi Piero","family":"Solimeno","sequence":"additional","affiliation":[{"name":"Ortopedic and Traumatology Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Pasta","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Clinic IRCCS Fondazione San Matteo Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Boccalandro","sequence":"additional","affiliation":[{"name":"Ortopedic and Traumatology Unit Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Fasulo","sequence":"additional","affiliation":[{"name":"Former: Angelo Bianchi Bonomi Haemophilia and Thrombosis Center Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisa","family":"Mancuso","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Haemophilia and Thrombosis Center Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Santagostino","sequence":"additional","affiliation":[{"name":"Angelo Bianchi Bonomi Haemophilia and Thrombosis Center Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"96","article-title":"Osteoporosis in haemophilic patient, rehabilitative aspects","volume":"9","author":"Franco P","year":"2012","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2002.00695.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01533.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2007.12.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12833"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2773-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02514.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01963.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-08-05563"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01405.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12197"},{"key":"e_1_2_7_14_1","unstructured":"Organization W. 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