{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:40:46Z","timestamp":1778658046579,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T00:00:00Z","timestamp":1546819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000102","name":"Health Resources and Services Administration","doi-asserted-by":"publisher","award":["H30MC24050-04-00"],"award-info":[{"award-number":["H30MC24050-04-00"]}],"id":[{"id":"10.13039\/100000102","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Among haemophilic (H) men, hepatitis C virus (HCV) is the leading cause of liver disease and mortality, but demographics and risks of hepatocellular carcinoma (HCC) in H are not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult discharges in H and non\u2010haemophilic (NH) men, with and without HCC were identified in the National Inpatient Sample (NIS) between 1998 and 2014, using ICD\u20109 codes. Analyses included NIS\u2010provided discharge\u2010level weights to reflect national estimates. Categorical variables were assessed by Rao\u2010Scott chi\u2010square and continuous variables by weighted simple linear regression. HCC predictors were determined by weighted multivariable logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 18\u00a0098 H, 144 (0.79%) had HCC between 1998 and 2014. Adjusted rates of HCC increased 3.0\u2010fold in H vs 1.7\u2010fold in NH (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.484). Among HCV+, HCC rates adjusted for HIV, increased 2.2\u2010fold in H vs 1.7\u2010fold in NH (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.740), while among HIV+, HCC increased 1.4\u2010fold in H vs 0.2\u2010fold in NH (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.448). Among those with HCC, H were older than NH (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), Caucasian (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006), platelet transfusion recipients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), with greater comorbidity (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and mortality (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.006). H with HCC also had greater rates of HCV and HIV (each <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), lower rates of alcoholism and hyperlipidemia (each <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), and similar rates of HBV (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.866), smoking (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.507) and obesity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.502). In multivariable logistic regression, HCV was a strong predictor for HCC in haemophilia, (OR: 15.42, 95% CI: 8.75\u201027.16).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Haemophilic men have increasing rates of HCC, similar to men without haemophilia. HCV is the major predictor of HCC in haemophilia. Future trends in HCC will depend on the impact of newer HCV antiviral therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13668","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:21:33Z","timestamp":1546996893000},"page":"221-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence and risk factors for hepatocellular cancer in individuals with haemophilia: A National Inpatient Sample Study"],"prefix":"10.1111","volume":"25","author":[{"given":"Alvin","family":"Thalappillil","sequence":"first","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh Pennsylvania"},{"name":"Haemophilia Center of Western Pennsylvania Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-5379","authenticated-orcid":false,"given":"Margaret V.","family":"Ragni","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Pittsburgh Pennsylvania"},{"name":"Haemophilia Center of Western Pennsylvania Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane M.","family":"Comer","sequence":"additional","affiliation":[{"name":"Center for Research on Health Care Data Center University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Yabes","sequence":"additional","affiliation":[{"name":"Center for Research on Health Care Data Center University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Division of General Internal Medicine University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Biostatistics University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_8_3_1","volume-title":"SEER*Stat Database: Incidence \u2014 SEER 9 Regs Research Data. 2009 Sub (1973\u20132007)","author":"Surveillance, Epidemiology, and End Results (SEER) Program","year":"2010"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.7753"},{"key":"e_1_2_8_5_1","first-page":"1767","article-title":"Kanwal F. Epidemiology of hepatocellular carcinoma in the United States: where are we? Where do we go?","volume":"60","author":"El \u2010Serag HB","year":"2014","journal-title":"Hepatol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/319273"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021423"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02366.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20534"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01935.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.11.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.7.1889.1889"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.08.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13244"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13178"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.13668","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T10:03:51Z","timestamp":1694081031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,7]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/hae.13668"],"URL":"https:\/\/doi.org\/10.1111\/hae.13668","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,7]]},"assertion":[{"value":"2018-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}