{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:47:31Z","timestamp":1762876051711,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilic arthropathy (osteoarthritis secondary to haemophilia) of the ankle may result in painful hindfoot malalignment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To analyse hindfoot alignment in subjects with haemophilic arthropathy of the ankle and evaluate the response (improvement of pain, function and alignment) to the orthotic treatment prescribed in patients with malalignment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 163 patients with haemophilia, all of them over 16\u00a0years of age. Hindfoot alignment and footprint were analysed in patients with and without haemophilic arthropathy of the ankle (as determined by the Pettersson score). Response to the use of an orthosis was evaluated at 6\u00a0months by means of the AOFAS Ankle\u2010Hindfoot Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six (59.5%) patients with haemophilic arthropathy presented with concomitant\u00a0 hindfoot malalignment. The most common abnormality was a valgus alignment combined with a neutral footprint. In 14 cases, valgus was associated with a <jats:italic>pes planu<\/jats:italic>s or a <jats:italic>pes cavus<\/jats:italic>. Only 5 patients without haemophilic arthropathy (7.2%) presented with some form of malalignment. The differences between the groups were statistically significant. The probability of having malalignment increased with the degree of arthropathy. Patients with haemophilic arthropathy and malalignment were treated with an orthosis, with insoles as the most commonly used alternative (86%). Such treatment significantly improved patients\u2019 pain and function\u2010related scores on the AOFAS Ankle\u2010Hindfoot Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the high rates of valgus malalignment in subjects with haemophilic arthropathy of the ankle, and the good response rates obtained following individualised orthotic treatment, it seems reasonable to routinely evaluate hindfoot alignment in this group of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13680","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T16:59:09Z","timestamp":1548089949000},"page":"500-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hindfoot malalignment in adults with haemophilic ankle arthropathy: The importance of early detection and orthotic treatment"],"prefix":"10.1111","volume":"25","author":[{"given":"Hortensia","family":"De la Corte\u2010Rodriguez","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation La Paz University Hospital\u2010IdiPaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-0113","authenticated-orcid":false,"given":"Emerito Carlos","family":"Rodriguez\u2010Merchan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery La Paz University Hospital\u2010IdiPaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Alvarez\u2010Roman","sequence":"additional","affiliation":[{"name":"Department of Hematology La Paz University Hospital\u2010IdiPaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Martin\u2010Salces","sequence":"additional","affiliation":[{"name":"Department of Hematology La Paz University Hospital\u2010IdiPaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3937-3499","authenticated-orcid":false,"given":"Victor","family":"Jimenez\u2010Yuste","sequence":"additional","affiliation":[{"name":"Department of Hematology La Paz University Hospital\u2010IdiPaz Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13484"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e3283422cf5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12779"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02711.x"},{"issue":"3","key":"e_1_2_8_6_1","first-page":"CD006801","article-title":"Custom\u2010made foot orthoses for the treatment of foot pain","author":"Hawke F","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","first-page":"235","volume-title":"Ortesis y Pr\u00f3tesis del Aparato Locomotor: Miembro Inferior","author":"Coh\u00ed O","year":"2005"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-6362(00)00075-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13274"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20353"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.05.014"},{"key":"e_1_2_8_12_1","first-page":"35","volume-title":"Quince Lecciones Sobre Patolog\u00eda del Pie","author":"Viladot A","year":"2000"},{"key":"e_1_2_8_13_1","first-page":"169","article-title":"Radiological evaluation of the flexibles pes planus treated with conic endorthesis","volume":"22","author":"Gonz\u00e1lez Trujano A","year":"2008","journal-title":"Acta Ortop Mex"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-010-1449-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100713505851"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2015.10.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110079501600911"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-009-0857-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1146-6-48"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1071100714523589"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.3.170066"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3113\/FAI.2011.0288"},{"issue":"3","key":"e_1_2_8_23_1","first-page":"7","article-title":"Radiographic scores and implications","volume":"30","author":"Pettersson H","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2011.03.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070302400108"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13184"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2013.05.008"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199710000-00015"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871529X17666170908110758"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-528414"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13202"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01720.x"},{"key":"e_1_2_8_33_1","first-page":"97","article-title":"Hindfoot deformities in adults. Conservative and surgical treatment","volume":"45","author":"G\u00f6tz J","year":"2016","journal-title":"Orthopade"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2004.12.001"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070302400608"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13680","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.13680","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:25:08Z","timestamp":1694042708000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/hae.13680"],"URL":"https:\/\/doi.org\/10.1111\/hae.13680","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2019,1,21]]},"assertion":[{"value":"2018-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}