{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:01:53Z","timestamp":1773046913154,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Differences in treatment and outcome have been reported for persons with haemophilia (PWH) on intermediate\u2010dose (Dutch) and high\u2010dose (Swedish) prophylaxis, but the potential influence of sports participation has not been considered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare sports participation and clinical outcome between adult Dutch and Swedish PWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010reported sports participation (type and frequency per week), physical functioning (SF\u201036<jats:sub>PF<\/jats:sub>: 100\u20100), joint status (HJHS: 0\u2010144), perceived limitations (HAL<jats:sub>sum<\/jats:sub>: 100\u20100) and physical activity (IPAQ) were recorded. Sports were classified according to National Haemophilia Foundation classification (5 categories, highest two were classified as high\u2010risk sports). Sports participation and clinical outcome were compared according to country and age (18\u201022, 23\u201029, 30\u201040\u00a0years) using non\u2010parametric tests and Spearman correlations (rho).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one adult PWH (NL: 43, SWE: 28) completed sports questionnaires (mean age: 26\u00a0years). All participants engaged in sports, including 59.2% in high\u2010risk sports (33.9% twice weekly). Dutch PWH showed a significant age\u2010related decline in (high\u2010risk) sports participation (7x\/wk in PWH 18\u201022\u00a0years to 2x\/wk in PWH 30\u201040\u00a0years, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), joint health (HJHS: median 2\u201015.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and physical functioning (SF\u201036<jats:sub>PF<\/jats:sub>: median 100 to 77.5, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), while Swedish did not. Sports participation was not associated with bleeding (Spearman's rho\u00a0=\u00a0\u22120.119).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>All participants reported sports participation, including 59.2% in high\u2010risk sports. Dutch PWH treated with intermediate\u2010dose prophylaxis showed an age\u2010related decline in sports participation, joint status and physical functioning, whereas Swedish PWH on high\u2010dose prophylaxis did not. Sports participation was not associated with bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13683","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T03:55:37Z","timestamp":1548734137000},"page":"244-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sports participation and physical activity in adult Dutch and Swedish patients with severe haemophilia: A comparison between intermediate\u2010 and high\u2010dose prophylaxis"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0748-1364","authenticated-orcid":false,"given":"Olav","family":"Versloot","sequence":"first","affiliation":[{"name":"Van Creveldkliniek, University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7195","authenticated-orcid":false,"given":"Erik","family":"Berntorp","sequence":"additional","affiliation":[{"name":"Clinical Coagulation Research Unit Lund University, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Translational Sciences, Faculty of Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Petrini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinic of Coagulation Disorders Karolinska Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Ljung","sequence":"additional","affiliation":[{"name":"Clinical Coagulation Research Unit, Lund University and Malm\u00f6 Centre for Thrombosis and Haemostasis Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-2483","authenticated-orcid":false,"given":"Jan","family":"Astermark","sequence":"additional","affiliation":[{"name":"Centre for Thrombosis and Haemostasis Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Translational Sciences, Faculty of Medicine Lund University  Malm\u00f6 Sweden"},{"name":"Coagulation Unit Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-6613","authenticated-orcid":false,"given":"Kathelijn","family":"Fischer","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, University Medical Center Utrecht Utrecht University Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01505.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02555.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2000.00422.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02904.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01456.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-470898"},{"key":"e_1_2_9_8_1","volume-title":"Playing it Safe: Bleeding Disorders, Sports and Exercise","author":"Anderson A","year":"2017"},{"key":"e_1_2_9_9_1","unstructured":"EuroStat. 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