{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:22Z","timestamp":1790205202212,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,27]],"date-time":"2019-10-27T00:00:00Z","timestamp":1572134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction and aims<\/jats:title><jats:p>Age\u2010related severity and distribution of haemophilic arthropathy (HA) among Chinese patients with haemophilia using the Haemophilia Early Detection with Ultrasound (HEAD\u2010US) system have not been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our study, 89 patients with moderate and severe haemophilia were recruited. A total of 534 joints (knees, ankles and elbows on both sides included) were evaluated using musculoskeletal ultrasound (MSKUS) and scored using the HEAD\u2010US system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prevalence and average number of HA were 39.1% and 0.7, 90.6% and 3.2, 94.1% and 4.5, and 100% and 4.3 for ages\u00a0\u226410, 11\u201020, 21\u201030 and 31\u201040\u00a0years, respectively. Prevalence and mean number of knee, ankle and elbow arthropathies also increased with age, although joint damages progressed in unparallel patterns. A significant difference in synovium subscores was observed between patients aged\u00a0&lt;10 and\u00a0&gt;10\u00a0years. An increasing tendency was observed in cartilage and subchondral bone subscores along with age before 30\u00a0years. No significant difference in mean joint scores was found between patients receiving on\u2010demand therapy and those receiving on\u2010demand to low\u2010dose prophylactic therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haemophilic arthropathy developed in early childhood and progressed mainly before 30\u00a0years of age among Chinese patients with haemophilia, although in different ways among the knee, ankle and elbow.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13858","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T03:24:29Z","timestamp":1572233069000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Age\u2010related severity and distribution of haemophilic arthropathy of the knee, ankle and elbow among Chinese patients with haemophilia"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8400-5073","authenticated-orcid":false,"given":"Sha","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010fu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010bin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping\u2010yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Nanjing First Hospital Nanjing Medical University Nanjing 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