{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:35:59Z","timestamp":1791657359615,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["950636"],"award-info":[{"award-number":["950636"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Radiocolloids labelled with less costly and more accessible radionuclides such as rhenium\u2010188 are of interest to developing countries compared with those labelled with rhenium\u2010186 and yttrium\u201090.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study was aimed to evaluate the efficacy and safety of radiosynovectomy using rhenium\u2010188 in patients with chronic haemophilic synovitis and recurrent hemarthrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this quasi\u2010experimental prospective study, 20 haemophilic patients were evaluated at preinjection, and at 1, 3, 6 and 12\u00a0months after injection. Magnetic resonance imaging (MRI) was done to measure synovial thickness and to calculate Denver score. Joint radiographs were taken to measure the Pettersson score. The Gilbert questionnaire, Functional Independence Score in Hemophilia (FISH) and visual analogue scale (VAS) for pain were completed, and the number of bleeding episodes and factor consumption were recorded at each follow\u2010up visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of bleeding episodes, the amount of factor consumption per month, VAS pain scores and synovial thickness decreased significantly over time (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Gilbert and FISH scores showed significant improvement (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). However, Pettersson score and Denver score showed no significant changes after injection. Minor complications including temporary pain and swelling occurred in 20% of patients, and no major complication was observed after rhenium\u2010188 injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicated high clinical impact, efficacy, safety and low invasion of rhenium\u2010188 in radiosynovectomy of haemophilic patients. Considering the availability and relatively low cost of rhenium\u2010188 in developing countries, this can be a good treatment option for haemophilic patients with recurrent hemarthrosis, particularly when the synovial hypertrophy is not massive yet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13880","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T10:01:07Z","timestamp":1575885667000},"page":"142-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rhenium\u2010188 radiosynovectomy for chronic haemophilic synovitis: Evaluation of its safety and efficacy in haemophilic patients"],"prefix":"10.1111","volume":"26","author":[{"given":"Amir R.","family":"Kachooei","sequence":"first","affiliation":[{"name":"Orthopedic Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Heidari","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasemali","family":"Divband","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department Faculty of Medical Sciences Behbahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad E.","family":"Zandinezhad","sequence":"additional","affiliation":[{"name":"Sarvar Clinic Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mousavian","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Farhangi","sequence":"additional","affiliation":[{"name":"Hemophilia\u2010Thalassaemia Center of Mashhad (Sarvar Clinic) Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Aminzadeh","sequence":"additional","affiliation":[{"name":"Department of Radiology Ghaem Hospital Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Zarifian","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Center for Excellence in Clinical Research Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8629-1854","authenticated-orcid":false,"given":"Farshid","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Orthopedic Research Center Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Badiei","sequence":"additional","affiliation":[{"name":"Hemophilia\u2010Thalassaemia Center of Mashhad (Sarvar Clinic) Mashhad University of Medical Sciences Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.08.023"},{"key":"e_1_2_9_3_1","first-page":"44","article-title":"Radiosynoviorthesis in hemophilic joints with yttrium\u201090 citrate and rhenium\u2010186 sulfide and long term results","volume":"16","author":"Teyssler P","year":"2013","journal-title":"Hell J Nucl Med"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2003.00799.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00913.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12273"},{"key":"e_1_2_9_7_1","first-page":"116","article-title":"Vicious cycle of multiple invasive treatments in a hemophilic inhibitor positive child with resistant knee flexion contracture, a case report","volume":"1","author":"Kachooei AR","year":"2013","journal-title":"Arch Bone Jt Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"396","DOI":"10.55095\/achot2013\/067","article-title":"[Recurrent intra\u2010articular bleeding episodes in haemophiliacs. Treatment outcomes in the patients at the university hospital motol in 1985\u20132005]","volume":"80","author":"Teyssler P","year":"2013","journal-title":"Acta Chir Orthop Traumatol Cech"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-200608000-00002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-011-0467-1"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0000000000000755"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(01)00228-1"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006231-199805000-00004"},{"key":"e_1_2_9_14_1","first-page":"609","article-title":"Better results with rhenium\u2010186 radiosynoviorthesis than with cortivazol in rheumatoid arthritis (RA): a two\u2010year follow\u2010up randomized controlled multicentre study","volume":"22","author":"Tebib JG","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-199405000-00019"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.13880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13880","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.13880","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.13880","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T13:41:01Z","timestamp":1693575661000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.13880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,9]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/hae.13880"],"URL":"https:\/\/doi.org\/10.1111\/hae.13880","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,9]]},"assertion":[{"value":"2019-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}