{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:56:33Z","timestamp":1780527393653,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Use of population pharmacokinetics (PopPK) to facilitate PK\u2010informed prophylaxis in clinical practice has gained momentum among haemophilia providers due to the accessibility of tools such as the Web Accessible Population Pharmacokinetic Service\u2014Hemophilia (WAPPS\u2010Hemo) and availability of extended half\u2010life (EHL) factor concentrates. It is unknown how clinicians implement PopPK.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the evolution of PopPK use in clinical practice by comparing blood sampling strategies, patient features, and factor group between initial and recent periods of WAPPS\u2010Hemo availability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PK data for haemophilia A and haemophilia B patients from two time periods were extracted from the WAPPS\u2010Hemo database: early availability (10\/2015\u201009\/2016) and recent use (10\/2017\u201009\/2018). We compared patient characteristics (age, body weight, haemophilia type), product type and dose, and blood sampling times between the time frames.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 1900 eligible infusions were submitted to WAPPS\u2010Hemo during the periods studied, with 85% representing FVIII concentrates. In the recent cohort, PK profiles were requested for younger patients (median age 18 vs 26\u00a0years), with increased proportional EHL FVIII use (29% vs 14% of infusions). High\u2010use centres generally submitted fewer blood samples per infusion than non\u2010high\u2010use centres, although the number of samples collected by non\u2010high\u2010use centres decreased significantly over time. During both periods, blood sample timing was generally consistent with ISTH recommended windows.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of WAPPS\u2010Hemo by haemophilia providers grew by over threefold between the time periods investigated. While sampling times have included key time points proposed first by Bj\u00f6rkman since early WAPPS\u2010Hemo usage, a trend towards minimizing sampling was observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13882","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T14:06:14Z","timestamp":1574172374000},"page":"56-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical application of Web Accessible Population Pharmacokinetic Service\u2014Hemophilia (WAPPS\u2010Hemo): Patterns of blood sampling and patient characteristics among clinician users"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-2603","authenticated-orcid":false,"given":"Alanna","family":"McEneny\u2010King","sequence":"first","affiliation":[{"name":"School of Pharmacy University of Waterloo Waterloo ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy HT","family":"Yeung","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea N.","family":"Edginton","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Waterloo Waterloo ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact McMaster University Hamilton ON Canada"},{"name":"Department of Medicine Clinical Epidemiology of Congenital Bleeding Disorders McMaster University Hamilton ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-6166","authenticated-orcid":false,"given":"Stacy E.","family":"Croteau","sequence":"additional","affiliation":[{"name":"Boston Hemophilia Center Boston Children\u2019s Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD003429","article-title":"Clotting factor concentrates given to prevent bleeding and bleeding\u2010related complications in people with hemophilia A or B","volume":"9","author":"Iorio A","year":"2011","journal-title":"Cochrane Database Syst 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