{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:58:18Z","timestamp":1780462698663,"version":"3.54.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004881","name":"Instituto Mexicano del Seguro Social","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004881","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Postpartum haemorrhage (PPH) is the main cause of maternal morbidity and mortality globally, but it is far more important in non\u2010developed countries. PPH represents 25% of all maternal deaths worldwide. Women with von Willebrand disease (VWD) and other inherited haemorrhagic disorders are at increased risk of PPH. Our aim was to establish a probable association of severe PPH in women with a history of haemostatic abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational, controlled study of adult women with a one or more episodes of severe PPH requiring treatment in an intensive care unit or &gt;10 units of blood products during the 24\u2010hour period after diagnosis and their controls. The tests performed were blood cell count, blood group, renal, viral, liver function and haemostatic tests, fibrinogen, activity of the plasma factors and specific test to diagnose and classify VWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 124 women with 133 PPH events and their controls. The median age at the first event was 25.5\u00a0years old. Results were significantly different between the groups in terms of fibrinogen concentration, VWF:Ag, VWF:RCo and FVIII. A specific diagnosis was established in 69 (55.6) and 4 (3.2%) patients in the PPH group and controls, respectively. Of 61 patients with VWD, 57 had type 1, two had type 2A, and another two had type 2B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show a relationship between PPH and inherited haemostatic disorders. VWD was the most frequent diagnosis. Appropriate and opportune diagnosis before pregnancy of inherited haemostatic disorders may be important to effectively prevent and treat PPH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13900","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T08:41:00Z","timestamp":1576053660000},"page":"97-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["von Willebrand Disease and other hereditary haemostatic factor deficiencies in women with a history of postpartum haemorrhage"],"prefix":"10.1111","volume":"26","author":[{"given":"Karim","family":"Majluf\u2010Cruz","sequence":"first","affiliation":[{"name":"Hemostasia y Aterog\u00e9nesis Unidad de Investigaci\u00f3n M\u00e9dica en Trombosis IMSS Ciudad de Mexico Mexico"},{"name":"Laboratorio de Farmacologia Molecular Escuela Superior de Medicina Instituto Politecnico Nacional Ciudad de Mexico 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