{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:59:37Z","timestamp":1772074777047,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["WI199899"],"award-info":[{"award-number":["WI199899"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilic ankle arthropathy due to repeated joint bleeds often leads to altered gait in adult patients with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between clinical gait features and blood\u2010induced ankle joint damage scored using MRI findings in patients with haemophilic ankle arthropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This observational study investigated 48 ankles of 24 patients with severe haemophilia (median age of 33\u00a0years). Blood\u2010induced ankle joint damage was scored by an experienced radiologist using the International Prophylaxis Study Group (IPSG\u2010)MRI score which evaluates the presence or absence of effusion, synovial hypertrophy, haemosiderin, surface erosions, subchondral cysts and cartilage degeneration. Using 3D gait analysis, peak ankle joint power generation and absorption (W\/kg) were measured for each ankle since these are surrogate measures for joint loading during walking. Associations between MRI findings and these two clinical gait features were calculated using Spearman's <jats:italic>\u03c1<\/jats:italic> correlation with an \u03b1\u2010level correction (<jats:italic>\u03b1<\/jats:italic>\u00a0=\u00a00.01) for multiple tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found large negative associations between ankle joint peak power generation and IPSG\u2010MRI score (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.631; <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;.001), IPSG\u2010MRI osteochondral subscore (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.701; <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;.001), severity of synovial hypertrophy (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.507; <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;.001) and haemosiderin (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.400; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Associations were also found for ankle joint peak power absorption and IPSG\u2010MRI score (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.425; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) and IPSG\u2010MRI osteochondral subscore (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a0\u22120.556; <jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Severe blood\u2010induced ankle joint damage relates to a lowered tolerance towards ankle joint mechanical loading during walking in patients with haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.13925","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T13:15:50Z","timestamp":1579094150000},"page":"333-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical gait features are associated with MRI findings in patients with haemophilic ankle arthropathy"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-4809","authenticated-orcid":false,"given":"Maarten","family":"Eerdekens","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences Musculoskeletal Rehabilitation Research Group KU Leuven Heverlee Belgium"},{"name":"Clinical Motion Analysis Laboratorium (CMAL) UZ Leuven Pellenberg Belgium"},{"name":"Haemophilia Center UZ Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathelijne","family":"Peerlinck","sequence":"additional","affiliation":[{"name":"Haemophilia Center UZ Leuven Leuven Belgium"},{"name":"Department of Cardiovascular Sciences KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"Staes","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences Musculoskeletal Rehabilitation Research Group KU Leuven Heverlee Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Baptiste","family":"Pialat","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier Lyon\u2010Sud Hospices Civils de Lyon Lyon France"},{"name":"Universit\u00e9 Claude Bernard Lyon 1 Universit\u00e9 de Lyon Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5429-8437","authenticated-orcid":false,"given":"C\u00e9dric","family":"Hermans","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3829-6850","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Lobet","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Cliniques Universitaires Saint\u2010Luc Brussels Belgium"},{"name":"Institut de Recherche Exp\u00e9rimentale et Clinique Neuromusculoskeletal Lab (NMSK) Universit\u00e9 Catholique de Louvain Brussels Belgium"},{"name":"Service de M\u00e9decine Physique et R\u00e9adaptation Cliniques Universitaires Saint\u2010Luc Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Clinical Motion Analysis Laboratorium (CMAL) UZ Leuven Pellenberg Belgium"},{"name":"Department of Rehabilitation Sciences Musculoskeletal Rehabilitation Research Group KU Leuven Brugge 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