{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:44Z","timestamp":1787014304992,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Total knee arthroplasty (TKA) can improve knee function in the general population, but challenges arise for TKA use in haemophilic patients (HPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to evaluate the midterm clinical experience of a single medical centre in TKA in HPs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a case series of consecutive TKAs from 2007 to 2013 in HPs. All patients received coagulation factor supplementation according to the institutional protocol. Surgery was performed without a tourniquet by a standard midline medial parapatellar approach. We compared the range of motion (ROM) and flexion contracture before surgery and 1\u2010year postoperative using paired Wilcoxon\u2010non\u2010parametric test (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05 was considered significant). The need for revision surgery was considered TKA survival failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010one HP\/60 TKAs were reviewed (19 cases were bilateral). Preoperative median ROM and flexion contracture was 75\u00b0 (range, 0\u00b0\u201095\u00b0) and 20\u00b0 (range, 5\u00b0\u201080\u00b0), respectively. The postoperative median ROM increased to 83\u00b0 (range, 45\u00b0\u2010110\u00b0), and median flexion contracture decrease to 0\u00b0 (range, 0\u00b0\u201040\u00b0) a statistically significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.01). Postoperative median clinical Knee Society Score (KSS) and functional KSS were 88 (range, 59\u201097) and 100 (range, 30\u2010100), respectively. Six patients required revision (6.66%) due to infection. TKA survival at 5\u00a0years was 92% (range, 82%\u201096%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study supports that TKA improves function and ROM in haemophilic knee arthropathy. The protocol of coagulation factors used in this cohort is valid as no related complications were reported. A higher incidence of complications, especially infections, must be expected compared with a TKA in non\u2010HPs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14004","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T14:01:42Z","timestamp":1587391302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Knee haemophilic arthropathy care in Chile: Midterm outcomes and complications after total knee arthroplasty"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5612-9418","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Oyarzun","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital San Jose Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9674-0553","authenticated-orcid":false,"given":"Cristian","family":"Barrientos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital San Jose Santiago Chile"},{"name":"Department of Orthopaedic Surgery Hospital Cl\u00ednico Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-8625","authenticated-orcid":false,"given":"Maximiliano","family":"Barahona","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital Cl\u00ednico Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-0839","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital San Jose Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Soto\u2010Arellano","sequence":"additional","affiliation":[{"name":"Centre of Haemophilia and Studies of Congenital Coagulopathies Roberto del Rio Children's Hospital Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Courtin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hospital San Jose Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-3368","authenticated-orcid":false,"given":"Carlos","family":"Cruz\u2010Montecinos","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy Faculty of Medicine University of Chile Santiago Chile"},{"name":"Biomechanics and Kinesiology Laboratory Service of Physical Therapy San Jos\u00e9 Hospital Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02834.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.92B8.23922"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13858"},{"key":"e_1_2_10_6_1","unstructured":"Ministerio de salud de Chile secretaria t\u00e9cnica AUGE.Guia Clinica AUGE Hemofilia.2013.http:\/\/www.repositoriodigital.minsal.cl\/handle\/2015\/503"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5867\/medwave.2013.05.5711"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2013.856261"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.09.029"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02894.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12244"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12698"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000011"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198911000-00004"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/230949900501300311"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.19250"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-01-0004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02579.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2013.07.014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.knee.2013.09.010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2020.01.014"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12832"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.08.274"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12643"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02530.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01553.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12157"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12885"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-05-0407"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fhae.14004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T01:35:28Z","timestamp":1693704928000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,20]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/hae.14004"],"URL":"https:\/\/doi.org\/10.1111\/hae.14004","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,20]]},"assertion":[{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}