{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:13:23Z","timestamp":1790205203527,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated joint health in Nordic patients in relation to their treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD\u2010US) and Haemophilia Joint Health Score (HJHS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report on 145 patients: median age 28\u00a0years (IQR 13\u201052) and 61% MHA. Baseline factor VIII\/factor IX activity (FVIII\/FIX:C) was 2\u00a0IU\/dL (median) (IQR 2\u20104): lower for MHB (2\u00a0IU\/dL, IQR 1\u20102) than MHA (3\u00a0IU\/dL, IQR 2\u20104) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Eighty\u2010five per cent of MHA and 73% MHB had a history of haemarthrosis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.07). Age at first joint bleed was lower for MHA (5\u00a0years [median], IQR 3\u20107) than MHB (7\u00a0years, IQR 5\u201012) (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). Thirty\u2010eight per cent received prophylaxis, started at median 10\u00a0years of age (IQR 4\u201024). Median joint bleeds and serious other bleeds during the last 12\u00a0months were both zero (IQR 0\u20101). Total HEAD\u2010US captured 0\/48 points (median) (IQR 0\u20102) and HJHS 4\/120 points (IQR 1\u201010) with strong correlation between them (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.72). FVIII\/FIX:C\u00a0\u2264\u00a03\u00a0IU\/dL was associated with higher HJHS (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.04). Fifteen per cent had undergone orthopaedic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current joint health in Nordic moderate haemophilia patients was rather good, but a subgroup had severe arthropathy. FVIII\/FIX:C\u00a0\u2264\u00a03\u00a0IU\/dL and MHA were associated with a more severe bleeding phenotype. We suggest primary prophylaxis to all patients with FVIII\/FIX:C\u00a0\u2264\u00a03\u00a0IU\/dL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14114","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T06:37:38Z","timestamp":1595918258000},"page":"891-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Joint health and treatment modalities in Nordic patients with moderate haemophilia A and B \u2013 The MoHem study"],"prefix":"10.1111","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-7089","authenticated-orcid":false,"given":"Ragnhild J.","family":"M\u00e5seide","sequence":"first","affiliation":[{"name":"Department of Haematology Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7195","authenticated-orcid":false,"given":"Erik","family":"Berntorp","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-2483","authenticated-orcid":false,"given":"Jan","family":"Astermark","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University  Malm\u00f6 Sweden"},{"name":"Department of Haematology Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-4880","authenticated-orcid":false,"given":"Anna","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bruzelius","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Surgery Karolinska Institute  Stockholm Sweden"},{"name":"Department of Haematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Frisk","sequence":"additional","affiliation":[{"name":"Pediatric Coagulation Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-7288","authenticated-orcid":false,"given":"Vuokko","family":"Nummi","sequence":"additional","affiliation":[{"name":"Coagulation Disorders Unit Haematology Comprehensive Cancer Centre Helsinki University Hospital and Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[{"name":"Coagulation Disorders Unit Haematology Comprehensive Cancer Centre Helsinki University Hospital and Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir E.","family":"Tj\u00f8nnfjord","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l A.","family":"Holme","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital  Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital  Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo 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evaluation of haemophilic joints by haemophilia physicians: a reliability study","volume":"13","author":"Fischer K","year":"2015","journal-title":"J Thromb 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