{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:38Z","timestamp":1792226798888,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Detection of early arthropathy is crucial for the management of haemophilia, but data on moderate haemophilia are limited. Therefore, we evaluated joint health and treatment modalities in Nordic patients with moderate haemophilia A (MHA) and B (MHB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore and compare the Haemophilia Early Arthropathy Detection with Ultrasound (HEAD\u2010US) and Haemophilia Joint Health Score (HJHS) to detect early arthropathy in moderate haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional, multicentre study covering Nordic patients with MHA and MHB. Arthropathy was evaluated by HEAD\u2010US and HJHS 2.1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We assessed 693 joints in 118 patients. HEAD\u2010US scores (medians [interquartile ranges]) were as follows: elbows 0 points (0\u20130), knees 0 (0\u20130) and ankles 0 (0\u20131). Respectively, by HJHS: elbows 0 (0\u20131), knees 0 (0\u20131) and ankles 0 (0\u20131). Cartilage (14%) and bone (13%) were most commonly affected by HEAD\u2010US. Frequent HJHS findings were crepitus on motion in knees (39%), and loss of flexion (23%) and extension (13%) in ankles. HEAD\u2010US correlated strongly with HJHS (elbows <jats:italic>r<\/jats:italic>\u00a0=\u00a0.70, knees <jats:italic>r<\/jats:italic>\u00a0=\u00a0.60 and ankles <jats:italic>r<\/jats:italic>\u00a0=\u00a0.65), but 24% had discordant scores. Joints with HJHS zero points, 5% captured HEAD\u2010US \u22651 point. Moreover, 26% had HJHS findings without HEAD\u2010US pathology. Notably, 31% of knees had crepitus on motion and normal HEAD\u2010US.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, the joints attained low scores implying good joint health. HEAD\u2010US correlated strongly with HJHS. In 5%, HEAD\u2010US detected subclinical pathology. Crepitus on motion was frequently reported despite normal HEAD\u2010US, thus not necessarily reflecting arthropathy. HEAD\u2010US therefore improves the joint assessment in moderate haemophilia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14245","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T19:10:07Z","timestamp":1612811407000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Haemophilia early arthropathy detection with ultrasound and haemophilia joint health score in the moderate haemophilia (MoHem) study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-7089","authenticated-orcid":false,"given":"Ragnhild J.","family":"M\u00e5seide","sequence":"first","affiliation":[{"name":"Department of Haematology Oslo University Hospital Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1337-7195","authenticated-orcid":false,"given":"Erik","family":"Berntorp","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-2483","authenticated-orcid":false,"given":"Jan","family":"Astermark","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Lund University Malm\u00f6 Sweden"},{"name":"Department of Haematology Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Hansen","sequence":"additional","affiliation":[{"name":"Rehabilitation Unit Emergency care\/Internal Medicine Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-4880","authenticated-orcid":false,"given":"Anna","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Medicine Sahlgrenska University Hospital Region V\u00e4stra G\u00f6taland Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bruzelius","sequence":"additional","affiliation":[{"name":"Molecular Medicine and Surgery Karolinska Institute Stockholm Sweden"},{"name":"Department of Haematology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Frisk","sequence":"additional","affiliation":[{"name":"Pediatric Coagulation Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4427-5159","authenticated-orcid":false,"given":"Magnus","family":"Aspdahl","sequence":"additional","affiliation":[{"name":"Function Allied Health Professionals Medical Unit Occupational Therapy and Physiotherapy Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-7288","authenticated-orcid":false,"given":"Vuokko","family":"Nummi","sequence":"additional","affiliation":[{"name":"Coagulation Disorders Unit Haematology Comprehensive Cancer Centre Helsinki University Hospital and Research Program in Systems Oncology Faculty of Medicine Helsinki University Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geir E.","family":"Tj\u00f8nnfjord","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l A.","family":"Holme","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital Oslo Norway"},{"name":"Research Institute of Internal Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20353"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12197"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-11-0874"},{"key":"e_1_2_10_6_1","first-page":"601","article-title":"Ultrasound evaluation of 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