{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:55:28Z","timestamp":1788447328554,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T00:00:00Z","timestamp":1612569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Information about temporal development of von Willebrand disease (VWD) incidence at a population level is scarce. To our knowledge, no study has described the incidence of VWD at a population level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To estimate overall and annual incidence rates of hospital diagnosed VWD in Denmark between 1995 and 2016 as well as the frequency of hospital treated bleeding episodes before and after VWD diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A registry\u2010based cohort study that included all Danish patients with a first diagnosis of VWD in Denmark, identified in the Danish National Patient Registry through 1995\u20102016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 1,035 patients with a diagnosis of VWD. The overall incidence rate of VWD in 1995\u20102016 was 8.6 (95% CI: 8.1\u20109.2). The annual age\u2010standardized incidence rate per 100\u00a0000 person\u2010years varied between 4.1 (95% CI: 2.4\u20105.9) in 1998 and 16.7 (95% CI: 13.1\u201020.3) in 2005. A prominent peak in rates appeared from 2002 to 2008. One and five years before VWD diagnosis, 6% and 11.5% of the patients had at least one hospital treated bleeding episode. One and five years after diagnosis, the corresponding percentages were 7.9% and 13.4%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results are the first population\u2010based estimates of VWD incidence. The incidence may be underestimated because asymptomatic individuals may not be diagnosed. The observed peak in incidence from 2002\u20102008 may be explained by increased medical attention, leading to more patients being diagnosed, rather than an actual increase in VWD incidence. However, overall, we observed no systematic changes in VWD incidence over the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14257","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T14:09:15Z","timestamp":1612793355000},"page":"277-282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence of von Willebrand disease in Denmark, 1995\u20102016: A cohort study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-0582","authenticated-orcid":false,"given":"Anne Sofie Dam","family":"Laursen","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B\u00f8jer","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen R.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Shire US Inc., a Takeda company Lexington MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily S.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Shire US Inc., a Takeda company Lexington MA USA"},{"name":"Janssen Research and Development Raritan NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone Hvitfeldt","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Haemophilia Center Department of Haematology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen Margrethe","family":"Mikkelsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,6]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"The Nordic working group on von Willebrand disease.Nordic guidelines for diagnosis and management of von Willebrand disease (VWD). Guidelines of the Nordic Hemophilia Council 2013;http:\/\/nordhemophilia.org\/library\/Files\/PDF\u2010skjol\/NHC_VWD_Guidelines_rev_Final_121212.pdf. Accessed October 21 2020."},{"issue":"1","key":"e_1_2_6_3_1","first-page":"19","article-title":"Association of hemophilia clinic directors of Canada","volume":"153","author":"Hemophilia and von Willebrand's disease: 1. 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Accessed February 14 2020."},{"key":"e_1_2_6_20_1","unstructured":"Erhvervede og medf\u00f8dte bl\u00f8dningstilstande (Aquired and hereditary bleeding disorders).2019;https:\/\/www.sundhed.dk\/sundhedsfaglig\/laegehaandbogen\/blod\/tilstande\u2010og\u2010sygdomme\/koagulationsforstyrrelser\/erhvervede\u2010og\u2010medfoedte\u2010bloedningstilstande\/. Accessed October 21 2020."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/aob.2017.12.07"},{"key":"e_1_2_6_22_1","unstructured":"The Danish Health Authority.Report for the medical specialty: Internal medicine: hematology (Rapport for specialet: Intern Medicin: h\u00e6matologi).2008;https:\/\/www.sst.dk\/\u2010\/media\/Viden\/Specialplaner\/Specialeplan\u2010for\u2010intern\u2010medicin \u2010c\u2010 \u2010h\u00e6matologi\/Specialerapport\u2010for\u2010Intern\u2010medicin\u2010haematologi.ashx?la=da&hash=C510D27A7ED2013BE4CAFB88F0AC0F41588A05FB. 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