{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:21:50Z","timestamp":1789017710058,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>In the network of U.S. comprehensive haemophilia treatment centres (HTCs), von Willebrand disease (VWD) is the most common bleeding disorder other than haemophilia. Estimates of the size and characteristics of the VWD population receiving treatment are useful for healthcare planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Estimate the prevalence and incidence of VWD among males and females receiving care at U.S. HTCs (HTC\u2010treated prevalence and incidence).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During the period 2012\u20132019, de\u2010identified surveillance data were collected on all VWD patients who visited an HTC including year of birth, sex, race, Hispanic ethnicity, VWD type, and laboratory findings and used to calculate period HTC\u2010treated prevalence by VWD type and sex. Data from patients born 1995\u20131999 were used to estimate HTC\u2010treated incidence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the period, 24,238 patients with a diagnosis of VWD attended HTCs; for 23,479 (96.9%), VWD type was reported or could be assigned. Age\u2010adjusted HTC\u2010treated prevalence was 8.6 cases\/100,000 (7.2\/100,000 for Type 1, 1.2\/100,000 for Type 2 and 1.7\/million for Type 3) and was twice as high in women as men (4.8 vs. 2.4 cases\/100,000) for Type 1 and similar by sex for Type 2 and Type 3. HTC\u2010treated Type 1 incidence increased over the period, averaging nearly threefold higher for women than men (26.2 vs. 9.9\/100,000 live births). Sex differences were less for Type 2 (2.2 vs. 1.4 cases\/100,000 births) and slight in Type 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prevalence and incidence of HTC\u2010treated VWD differ by sex and type and are likely strongly influenced by differences in rates of diagnosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14263","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T06:47:26Z","timestamp":1617000446000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Occurrence rates of von Willebrand disease among people receiving care in specialized treatment centres in the United States"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-6824","authenticated-orcid":false,"given":"John Michael","family":"Soucie","sequence":"first","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention Atlanta GA USA"},{"name":"Synergy America, Inc Duluth GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie H.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention Atlanta GA USA"},{"name":"Synergy America, Inc Duluth GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa R.","family":"Byams","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1027-7639","authenticated-orcid":false,"given":"Amanda B.","family":"Payne","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karon","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Robert F.","family":"Sidonio","sequence":"additional","affiliation":[{"name":"Department of Medicine Emory University School of Medicine and Aflac Cancer and Blood Disorders Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Kouides","sequence":"additional","affiliation":[{"name":"Mary M. 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