{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:59:54Z","timestamp":1787839194609,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T00:00:00Z","timestamp":1614124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Effective physiotherapy interventions are required for haemophilic arthropathy (HA) of the elbow due to its biomechanical differences and contribution to upper limb functionality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effects of manual therapy &amp; exercises on bleeding frequency, pain, range of motion (ROM), strength, joint health, functionality and quality of life (QoL) in HA of the elbow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventeen participants with HA of the elbow were randomized as Manual Therapy &amp; Exercises Group (MTEG\u00a0=\u00a09) and Home Exercises Group (HEG\u00a0=\u00a08). Soft tissue mobilization, joint traction (grade I\u2010II) and Mulligan's mobilization with movement as manual therapy, and stretching\/strengthening exercises were applied to MTEG, while HEG had only same exercises as home programme. The interventions lasted 3\u00a0days\/weekly for 5\u00a0weeks. Bleeding frequency was evaluated with patients\u2019 records; pain with Numeric Pain Scale; ROM with goniometer; strength with digital dynamometer; joint health with HJHS; functionality with Quick\u2010Disability of Arm, Shoulder and Hand questionnaire; and QoL with Oxford Elbow Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bleeding frequency and activity pain were decreased, while elbow ROMs and flexor strength were increased in MTEG (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05). Also significantly improvements were seen in joint health, functionality and QoL in MTEG. HEG showed improvements in activity pain, QoL and some ROMs. MTEG had better results in ROMs, joint health and functionality (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Manual therapy &amp; exercises may be used without causing bleeding and pain to increase the functionality, joint health and QoL, and is superior to home exercise for joint health and functionality. Home exercises may be ameliorated in pain, QoL and some ROMs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14281","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T20:41:58Z","timestamp":1614199318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effects of manual therapy and exercises on pain, muscle strength, joint health, functionality and quality of life in haemophilic arthropathy of the elbow joint: A randomized controlled pilot study"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6232-1860","authenticated-orcid":false,"given":"Ayse Merve","family":"Tat","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences Department of Physiotherapy and Rehabilitation Necmettin Erbakan University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-9956","authenticated-orcid":false,"given":"Filiz","family":"Can","sequence":"additional","affiliation":[{"name":"Faculty of Physical Therapy and Rehabilitation Hacettepe University Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5858-2718","authenticated-orcid":false,"given":"Necati Muhammed","family":"Tat","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Department of Physiotherapy and Rehabilitation Necmettin Erbakan University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-9838","authenticated-orcid":false,"given":"Hatice Ilgen","family":"Sasmaz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pediatric Hematology and Oncology Cukurova University Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6058-6021","authenticated-orcid":false,"given":"Ali Bulent","family":"Antmen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Ac\u0131badem Hospital Adana Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01876.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02833.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163060-00002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0884-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.180090"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040620718784834"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.0050s1016.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215519879212"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2018.1425513"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/305249"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/09593985.2014.902148"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09593985.2020.1744207"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1000035","DOI":"10.2340\/20030711-1000035","article-title":"Manual therapy effectively decreases the frequency of joint bleeding improves joint health and reduces pain in hemophilic elbow arthropathy: a prospective cohort study","volume":"3","author":"P\u00e9rez\u2010Llanes R","year":"2020","journal-title":"JRM\u2010CC"},{"key":"e_1_2_9_15_1","volume-title":"Ligamentous Articular Strain: Osteopathic Manipulative Techniques for the Body","author":"Speece Conrad A","year":"2009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1179\/jmt.1993.1.2.47"},{"key":"e_1_2_9_17_1","volume-title":"Manuel Terapi","author":"Mulligan BR","year":"2015"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.37.4.378"},{"key":"e_1_2_9_19_1","volume-title":"Joint motion: method of measuring and recording","author":"American Academy of Orthopaedic Surgeons","year":"1965"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/76.3.248"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2006.01312.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12197"},{"issue":"3","key":"e_1_2_9_23_1","first-page":"99","article-title":"Kol, omuz ve el sorunlar\u0131 (disabilities of the arm, shoulder and hand\u2010DASH) anketi T\u00fcrk\u00e7e uyarlamas\u0131n\u0131n g\u00fcvenirli\u011fi ve ge\u00e7erli\u011fi","volume":"17","author":"D\u00fcger T","year":"2006","journal-title":"Fizyoterapi Rehabilitasyon"},{"issue":"5","key":"e_1_2_9_24_1","first-page":"1038","article-title":"Development of the QuickDASH: comparison of three item\u2010reduction approaches","volume":"87","author":"Beaton DE","year":"2005","journal-title":"JBJS"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-016-0429-3"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182557"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.90B4.20290"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-018-1934-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1067\/mmt.2002.127073"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1992.16.1.30"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12349"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12909"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12111"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.math.2008.09.001"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.1999.0050s1010.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2007.09.015"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13027"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13025"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1543997"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01867.x"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S84848"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02857.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.10.014"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T02:35:53Z","timestamp":1693190153000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,24]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/hae.14281"],"URL":"https:\/\/doi.org\/10.1111\/hae.14281","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,24]]},"assertion":[{"value":"2020-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}