{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:10:17Z","timestamp":1793304617586,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Patients with haemophilia (PwH) may experience increased sensitivity to pain. Based on the assessment of the somatosensory system, a recent study showed a specific pain profile in PwH when compared to controls by using Quantitative Sensory Testing (QST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to evaluate the pain profile of affected joints (knee or ankle joints) and a non\u2010affected site (dominant hand) in adult PwH over a 1\u2010year period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010four PwH (severe haemophilia A\u00a0=\u00a019, B\u00a0=\u00a03; moderate haemophilia A\u00a0=\u00a01, B\u00a0=\u00a01; age: 52\u00b18 years) and 21 healthy controls (age: 52\u00b112 years) were examined by QST. Both knee or ankle joints and the hand as reference were examined twice with an interval of 1\u00a0year in order to assess several detection (DT) and pain thresholds (PT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant altered mechanical (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) and pressure (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) PT were found at affected joints and at a non\u2010affected site in PwH when compared to controls. Mechanical DT showed a significant increase at all assessed sites (e.g., at ankle joints PwH vs. controls at baseline\/follow up in mN: 13.9\u00b19.8\u00a0vs. 12.0\u00b18.2\/19.4\u00b112.4\u00a0vs. 13.7\u00b111.1; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) in both cohorts. Nevertheless, changes in most parameters within 1\u00a0year occurred similarly in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The statistically significant different QST profile between PwH and controls does not seem to deteriorate further over the course of the year. Thus, under prophylactic treatment, the existing difference in the pain profile between PwH and controls at baseline does not appear to be a progressive process within 1\u00a0year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14380","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T01:55:22Z","timestamp":1628906122000},"page":"783-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Changes in pain profile of patients with haemophilia during 1\u2010year follow\u2010up"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1294-3036","authenticated-orcid":false,"given":"Steffen","family":"Kr\u00fcger","sequence":"first","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Moritzstr Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Herzig","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Moritzstr Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0935-2526","authenticated-orcid":false,"given":"Thomas","family":"Hilberg","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine University of Wuppertal  Moritzstr Wuppertal 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