{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T23:24:13Z","timestamp":1750202653670,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>While it has been shown that haemophilia patients receiving care at Haemophilia Treatment Centres (HTCs) experience decreased morbidity and mortality, little research has been done on the outcomes of patients with von Willebrand disease (VWD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the quality of periprocedural care received by patients with VWD at HTCs and non\u2010HTCs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review on all adult VWD patients undergoing an invasive procedure from 2015 to 2017. Quality of periprocedural care was measured using the following surrogate outcomes: periprocedural VWD\u2010specific therapy use per 2007 National Heart, Lung, and Blood Institute (NHLBI) guidelines, procedural estimated blood loss (EBL), and post\u2010procedure bleeding. Comparisons were performed according to the setting of care at the time of the invasive procedure, HTC versus non\u2010HTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 668 invasive procedures performed on 305 patients, of which 8.2% were HTC cases. Non\u2010type 1 VWD was more likely in HTC cases. VWD\u2010specific therapy was used per NHLBI guidelines in 100% of HTC cases compared with 10.6% of non\u2010HTC cases. Procedural EBL\u00a0&gt;\u00a0=\u00a0100\u00a0ml was more likely to occur in HTC differences cases (OR\u00a0=\u00a02.34; 95% CI, 1.05 to 5.25). There was no difference in post\u2010procedure bleeding between the two groups (OR\u00a0=\u00a01.26, 95% CI, .20\u2010 7.86).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite widespread periprocedural use of VWD\u2010specific therapy outside established guidelines at non\u2010HTCs, there was no difference in periprocedural bleeding. Possible explanations include diagnostic error, in disease severity and procedure types, and dataset limitations. Additional studies are needed to investigate this further and compare other patient care outcomes between HTCs and non\u2010HTCs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14389","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T16:31:42Z","timestamp":1628008302000},"page":"830-836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Quality of periprocedural care in patients with von Willebrand disease"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-1660","authenticated-orcid":false,"given":"Craig D.","family":"Seaman","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Hematology\/Oncology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Hemophilia Center of Western Pennsylvania  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marnie","family":"Bertolet","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology Biostatistics, and the Clinical and Translational Science Institute  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-5379","authenticated-orcid":false,"given":"Margaret V.","family":"Ragni","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology\/Oncology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"},{"name":"Hemophilia Center of Western Pennsylvania  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13008"},{"key":"e_1_2_10_3_1","first-page":"395","article-title":"Comprehensive care for hemophilia and related inherited bleeding disorders; why it matters","volume":"2","author":"Hoots WK","year":"2003","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_10_4_1","first-page":"437","article-title":"Mortality among males with hemophilia: relations with source of medical care","volume":"96","author":"Soucie JM","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.74.6.616"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14598"},{"volume-title":"The Diagnosis, Evaluation, and Management of Von Willebrand Disease","year":"2007","author":"Nichols WL","key":"e_1_2_10_7_1"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.08.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02909.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02915.x"},{"volume-title":"Von Willebrand Disease. Data and Statistics on Von Willebrand Disease","year":"2020","author":"Centers for Disease Control and Prevention","key":"e_1_2_10_11_1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13258"},{"volume-title":"MASAC Recommendations on the Care and Treatment of Individuals with Von Willebrand Disease","year":"2020","author":"Medical and Scientific Advisory Council","key":"e_1_2_10_13_1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12841"},{"key":"e_1_2_10_15_1","first-page":"2481","article-title":"Clinical and laboratory variability in a cohort of patients diagnosed with type 1 von Willebrand disease in the United States","volume":"127","author":"Flood VH","year":"2016","journal-title":"J Thromb Haemost"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25393"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-10-249102"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T11:15:43Z","timestamp":1693307743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/hae.14389"],"URL":"https:\/\/doi.org\/10.1111\/hae.14389","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2020-09-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}