{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:24:49Z","timestamp":1780597489618,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The COVID\u201019 pandemic has resulted in lifestyle changes for children. The aim of this study was to evaluate the impact of the pandemic on weight\/BMI in children with severe bleeding disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective review of patients age 3\u201318 years with severe bleeding disorders on prophylactic therapy treated at SickKids Hospital (Toronto, Canada) between February 01, 2018 and March 31, 2021. We evaluated the following pre\u2010 and post\u2010COVID variables: weight (kg), weight percentile, BMI (kg\/m<jats:sup>2<\/jats:sup>), BMI percentile, HJHS score, and prophylactic dosing (units\/kg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four patients were included in the final analysis.\u00a0Diagnoses were as follows:\u00a0\u00a0haemophilia A (<jats:italic>n<\/jats:italic>\u00a0=\u00a092; 70.8%), haemophilia B (<jats:italic>n<\/jats:italic>\u00a0=\u00a017; 13.1%), type 3 von Willebrand disease (<jats:italic>n<\/jats:italic>\u00a0=\u00a011; 8.5%), the remainder were diagnosed with rare factor deficiencies.\u00a0\u00a0Median interval time from pre\u2010COVID measurements to latest follow\u2010up was 12.4 months (IQR 10.32\u201314.52 months) during which there was a statistically significant increase in median weight percentile +5.75 centiles (from 63<jats:sup>rd<\/jats:sup>centile to 68.75<jats:sup>th<\/jats:sup>centile).\u00a0There was a statistically significant increase in mean BMI of +1.03\u00a0kg\/m<jats:sup>2<\/jats:sup>(<jats:italic>P<\/jats:italic>\u00a0=\u00a0&lt;\u00a0.001) while median BMI percentile increased +8.82 centiles (from 53.9<jats:sup>th<\/jats:sup>centile to 62.72<jats:sup>nd<\/jats:sup>centile) and mean BMI percentile increased 3.42 centiles (from 57.5 centile to 60.9 centile).\u00a0The group that gained the most weight centiles, BMI and BMI centiles were 5\u201314 years old.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a trend to weight gain over the study period. More long\u2010term data is required to evaluate the impact of this increase in weight and BMI on children with bleeding disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14449","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T03:41:08Z","timestamp":1636602068000},"page":"91-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Excess weight gain in the paediatric bleeding disorders population: Impact of the COVID\u201019 Pandemic"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-7022","authenticated-orcid":false,"given":"Caroline","family":"Malcolmson","sequence":"first","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children University of Toronto Department of Paediatrics  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Tetzlaff","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation The Hospital for Sick Children University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Maguire","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The Hospital for Sick Children University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Wakefield","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children University of Toronto Department of Nursing  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-1763","authenticated-orcid":false,"given":"Manuel","family":"Carcao","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children University of Toronto Department of Paediatrics  Toronto ON Canada"},{"name":"Research Institute The Hospital for Sick Children University of Toronto Child Health Evaluative Sciences  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-6445","authenticated-orcid":false,"given":"Vanessa","family":"Bouskill","sequence":"additional","affiliation":[{"name":"Division of Haematology\/Oncology The Hospital for Sick Children University of Toronto Department of Nursing  Toronto ON Canada"},{"name":"Research Institute The Hospital for Sick Children University of Toronto Child Health Evaluative Sciences  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/585085"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"\u201dNew normal\u201c routine: the impact of COVID\u201019 pandemic on chronodisrupture and its consequence on obesity","author":"Boaventura B","year":"2021","journal-title":"Chronobiol Int"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18020703"},{"key":"e_1_2_7_5_1","unstructured":"Canadian Consumers Prepare for COVID\u201019. 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