{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:10:48Z","timestamp":1747185048727,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Joint damage in haemophilia often requires surgical correction. However, the surgery effect on bleeding rates and other clinical joint outcomes can be unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the effects of joint surgery on joint annualized bleeding rates (JABRs) and physical health outcomes in patients with haemophilia A undergoing N8\u2010GP prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients in the pathfinder 2 trial received N8\u2010GP prophylaxis, enrolling in the pathfinder 3 trial for indicated surgery. Patients returned to pathfinder 2 post\u2010surgery, continuing N8\u2010GP prophylaxis until end\u2010of\u2010trial. JABRs were calculated from bleeding across all joints for pre\u2010surgery (immediately before surgery) and post\u2010surgery (to pathfinder 2 study end) periods. Joint\u2010health\u2010related outcomes were derived from patient records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data (41 joint surgeries; <jats:italic>n<\/jats:italic>\u00a0=\u00a030) were analysed statistically using datamining and descriptively. Pre\u2010surgery mean JABR was higher in patients who later were operated than in 146 non\u2010operated patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). In operated patients, mean JABR decreased from 1.33 pre\u2010surgery to .37 post\u2010surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.011). In all but three patients, JABR improved or remained the same post\u2010surgery. In the three patients whose JABR remained at one (all with multiple joint arthropathy), post\u2010surgery bleeds were mostly at non\u2010operated sites. Two of the three patients whose JABR increased post\u2010surgery had undergone surgery for reasons unlikely to improve JABR. Mobility parameters often improved in patients whose JABR remained at zero.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with haemophilia treated with N8\u2010GP prophylaxis benefit from surgeries. However, this analysis could not differentiate the relative contributions of surgical interventions and prophylactic treatment to the improvement of JABR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14460","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T04:37:48Z","timestamp":1637642268000},"page":"158-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical outcomes after joint surgery in patients on turoctocog alfa pegol (N8\u2010GP) prophylaxis: A <i>post hoc<\/i> analysis"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-7197","authenticated-orcid":false,"given":"Kingsley","family":"Hampton","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Science University of Sheffield  Sheffield UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3600-8536","authenticated-orcid":false,"given":"Andreas","family":"Tiede","sequence":"additional","affiliation":[{"name":"Department of Haematology Haemostasis, Oncology and Stem Cell Transplantation Hannover Medical School  Hanover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shwetha","family":"Shivamurthy","sequence":"additional","affiliation":[{"name":"Novo Nordisk  Bengaluru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-8586","authenticated-orcid":false,"given":"Pratima","family":"Chowdary","sequence":"additional","affiliation":[{"name":"Katharine Dormandy Haemophilia and Thrombosis Centre Royal Free Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13549"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-06-0444"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14958"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14959"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13246"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13980"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.11.032"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13811"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12195"},{"key":"e_1_2_11_12_1","first-page":"S112","article-title":"Current challenges in the management of hemophilia","volume":"21","author":"Bauer KA","year":"2015","journal-title":"Am J Manag Care"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S196103"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01065.x"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:52:55Z","timestamp":1692989575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,22]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hae.14460"],"URL":"https:\/\/doi.org\/10.1111\/hae.14460","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2021,11,22]]},"assertion":[{"value":"2021-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}