{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:16:22Z","timestamp":1760015782747,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,1]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Obesity is associated with endothelial dysfunction, haemostatic and fibrinolytic disturbances, however the impact of obesity on von Willebrand factor (VWF) is unclear.<\/jats:p><\/jats:sec>Aim<\/jats:title>The aim of this study was to test our hypothesis that the prevalence of obesity is higher among participants with low VWF (LVWF) compared to type 1 von Willebrand disease (T1VWD).<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective review of the ATHNdataset as of March 2018 was performed. Participants were categorized as T1VWD if their VWF ristocetin cofactor activity was 30\u00a0IU\/dL and LVWF if the values were 30\u201350\u00a0IU\/dL, and by the NIH definitions for body mass index (BMI) for adult participants (\u2265\u00a018 years of age) or BMI z\u2010score for paediatric participants (<\u00a018 years).<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of obesity was not significantly different between adults with T1VWD (n\u00a0=\u00a0<\/jats:italic>186) and LVWF (n<\/jats:italic>\u00a0=\u00a0362) (32%\u00a0vs 36%; p\u00a0=\u00a0<\/jats:italic>.345). The mean factor VIII (FVIII) increased with increasing BMIs in both groups. In the paediatric cohort (T1VWD, n<\/jats:italic>\u00a0=\u00a0583; LVWF, n<\/jats:italic>\u00a0=\u00a01702), there was no difference in the prevalence of obesity, but BMI was positively correlated with mean FVIII (p<\/jats:italic>\u00a0<\u00a0.001). Children\u00a0<\u00a010 years were 27.6% more likely to be diagnosed with T1VWD compared to\u00a0>\u00a010 years.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Among participants in the ATHNdataset, the prevalence of obesity was similar among those with LVWF and T1VWD. However, higher BMI levels were associated with elevated FVIII. Further research is needed to evaluate the impact of obesity on bleeding phenotype and treatment practices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14467","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T11:19:36Z","timestamp":1638875976000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of obesity on factor VIII and von Willebrand factor levels in patients with Type 1 von Willebrand disease and low von Willebrand factor: An analysis of the ATHNdataset"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5427-9666","authenticated-orcid":false,"given":"Beverly A.","family":"Schaefer","sequence":"first","affiliation":[{"name":"University at Buffalo Roswell Park Oishei Children's Cancer and Blood Disorders Program Buffalo NY USA"},{"name":"Western New York BloodCare Buffalo New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dunlei","family":"Cheng","sequence":"additional","affiliation":[{"name":"American Thrombosis and Hemostasis Network Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-8313","authenticated-orcid":false,"given":"Peter","family":"Kouides","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine Mary M. Gooley Hemophilia Treatment Center Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,7]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Prevalence of obesity among adults and youth: United States: 2015\u20132016","author":"Hales CMCM","year":"2017","journal-title":"NCHS Data brief"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25499"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.01.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.710509"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12225"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649589"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00975.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2006.06.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24962"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.168013"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003265"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1612981"},{"key":"e_1_2_9_14_1","article-title":"Prevalence of obesity and severe obesity among adults: united States, 2017\u20132018","author":"Hales CMCM","year":"2020","journal-title":"National Center for Health Statistics"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.008"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24860"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1351-8216.2003.00832.x"},{"key":"e_1_2_9_18_1","article-title":"Occurrence rates of von Willebrand disease among people receiving care in specialized treatment centres in the United States","author":"Michael Soucie J","year":"2021","journal-title":"Haemophilia"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002081"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12586"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14265"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15277"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1713636"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25869"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14467","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:52:11Z","timestamp":1692989531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,7]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/hae.14467"],"URL":"https:\/\/doi.org\/10.1111\/hae.14467","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2021,12,7]]},"assertion":[{"value":"2021-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}