{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:10:49Z","timestamp":1775466649935,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The negative impact of haemophilia on social participation is well established in previous studies, however, the impact of Von Willebrand disease (VWD) on social participation has not been studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the social participation of a large cohort of VWD patients in the Netherlands with the general Dutch population. In addition, to identify factors associated with social participation in VWD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients participating in the \u201cWillebrand in the Netherlands\u201d study completed an extensive questionnaire on educational level, absenteeism from school or work, and occupational disabilities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven\u2010hundred and eighty\u2010eight VWD patients were included (mean age 38.9 years, 59.5% females), of whom 136 children\u00a0&lt;\u00a016 years. Adult patients with type 3 VWD more often had a low educational level (52.9%) compared to type 1 (40.2%), type 2 VWD (36.8%) and the general population (36.4%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005). Moreover, in patients aged \u226516 years the days lost from school and\/or work in the year prior to study inclusion differed significantly between the VWD types (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.011). Using negative binomial regression analysis, the occurrence of bleeding episodes requiring treatment in the year preceding study inclusion was significantly associated with the number of days lost from school and\/or work among patients aged \u226516 years. Multivariable logistic regression analysis showed that a higher total bleeding score, older age and presence of at least one comorbidity were significantly associated with occupational disability in patients aged \u226516 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that social participation was lower in type 3 VWD and VWD patients with a more severe bleeding phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14475","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T13:11:03Z","timestamp":1640783463000},"page":"278-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Social participation is reduced in type 3 Von Willebrand disease patients and in patients with a severe bleeding phenotype"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9458-8674","authenticated-orcid":false,"given":"Eva K.","family":"Kempers","sequence":"first","affiliation":[{"name":"Department of Haematology Erasmus MC University Medical Centre Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin B.","family":"van Kwawegen","sequence":"additional","affiliation":[{"name":"Department of Haematology Erasmus MC University Medical Centre Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joke","family":"de Meris","sequence":"additional","affiliation":[{"name":"Netherlands Haemophilia Society  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saskia E. 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