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The tools to control bleeding in VWD are dominated by VWF concentrates, desmopressin and antifibrinolytic therapy. In view of these treatments being considered as effective, it is surprising that quality\u2010of\u2010life studies consistently demonstrate a significant mental and physical burden in VWD patients, particularly in women. Apparently, the current weaponry to support the management of VWD is insufficient to fully address the needs of the patients. It is important therefore to continue to search for innovative treatment options which could better serve the VWD patients. In this short review, two of such options are discussed in more detail: emicizumab to correct for the deficiency of factor VIII (FVIII), and the pegylated aptamer BT200 to increase endogenous levels of the VWF\/FVIII complex.<\/jats:p>","DOI":"10.1111\/hae.14518","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T10:07:08Z","timestamp":1651831628000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Towards novel treatment options in von Willebrand disease"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-3429","authenticated-orcid":false,"given":"Peter J.","family":"Lenting","sequence":"first","affiliation":[{"name":"Laboratory for Hemostasis, Inflammation &amp; Thrombosis, Unit\u00e9 Mixed de Recherche (UMR)\u20101176, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Kizlik\u2010Manson","sequence":"additional","affiliation":[{"name":"Laboratory for Hemostasis, Inflammation &amp; Thrombosis, Unit\u00e9 Mixed de Recherche (UMR)\u20101176, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Casari","sequence":"additional","affiliation":[{"name":"Laboratory for Hemostasis, Inflammation &amp; Thrombosis, Unit\u00e9 Mixed de Recherche (UMR)\u20101176, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm) Universit\u00e9 Paris\u2010Saclay  Le Kremlin\u2010Bic\u00eatre 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