{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:12:11Z","timestamp":1793643131745,"version":"4.5.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has created an unprecedented global health crisis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the impact of the 1<jats:sup>st<\/jats:sup> COVID\u201019 lockdown on haemophilia patients in terms of symptoms, management, medication adherence, mental health and lifestyle behaviours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective cross\u2010sectional phone survey using a two\u2010part questionnaire was conducted in haemophilia patients (adults and children) followed\u2010up in a French Haemophilia Comprehensive Care Centre between May 5, 2020 and June 2, 2020 (CLEO CD study: NCT04390126).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 284 haemophilia A or B patients with FVIII or FIX\u00a0&lt;\u00a040% contacted for the study, 239 (84%) including 183 adults and 56 children participated to the survey. In 81% of children and 78% of adults, bleeding episodes remained unchanged or decreased. Medication adherence was 82.0% in adults and 98.2% in children. Non\u2010adherence concerned haemostatic agents in six patients and analgesics in three. Overall, 67% of adults and 71% of children felt as good as before lockdown. In both adults and children, the three major changes in lifestyle behaviours were: increase in screen time (49% and 57%), decrease in physical activity (43% and 48%), and weight gain (32% and 27%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Encouraging results were observed in terms of haemophilia symptoms, medication adherence, and mental health. Conversely, a negative impact was observed on lifestyle behaviours in a cohort of French haemophilia patients during the 1<jats:sup>st<\/jats:sup> lockdown.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14526","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T12:49:44Z","timestamp":1646311784000},"page":"462-471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of first COVID\u201019 lockdown on paediatric and adult haemophilia patients treated in a French Haemophilia Comprehensive Care Centre"],"prefix":"10.1111","volume":"28","author":[{"given":"Fabienne","family":"Volot","sequence":"first","affiliation":[{"name":"Haemophilia Comprehensive Care Centre University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Soudry\u2010Faure","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation (DRCI) Clinical Research Unit\u2010 Methodological Support Network (USMR) University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria","family":"Callegarin","sequence":"additional","affiliation":[{"name":"Haemophilia Comprehensive Care Centre University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00e9a","family":"Ksiazek","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation (DRCI) Clinical Research Unit\u2010 Methodological Support Network (USMR) University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Delienne","sequence":"additional","affiliation":[{"name":"Haemophilia Comprehensive Care Centre University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Cottin","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maynadi\u00e9","sequence":"additional","affiliation":[{"name":"Biological Haematology Department University Hospital, and Haematological Malignancies Registry INSERM U1231 Burgundy University  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3504-7250","authenticated-orcid":false,"given":"Mathieu","family":"Boulin","sequence":"additional","affiliation":[{"name":"Pharmacy Department and EPICAD LNC UMR 1231 University Hospital  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Statista.Health Pharma and Medtech.https:\/\/www.statista.com\/statistics\/1093256\/novel\u2010coronavirus\u20102019ncov\u2010deaths\u2010worldwide\u2010by\u2010country\/. Accessed: July 17 2021."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.103022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14108"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061643"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17062032"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.112915"},{"key":"e_1_2_9_8_1","first-page":"288","article-title":"Health management of breast cancer patients outside the hospital during the outbreak of 2019 novel coronavirus disease","volume":"42","author":"Liu BL","year":"2020","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14156"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S257225"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14130"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14055"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14044"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1818066"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14189"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajp.2020.102066"},{"key":"e_1_2_9_19_1","unstructured":"World Federation of Haemophilia.COVID\u201019 (coronavirus disease 2019) pandemic caused by SARS\u2010CoV\u20102: practical recommendations for people with hemophilia.https:\/\/news.wfh.org\/covid\u201019\u2010coronavirus\u2010disease\u20102019\u2010pandemic\u2010caused\u2010by\u2010sars\u2010cov\u20102\u2010practical\u2010recommendations\u2010for\u2010hemophilia\u2010patients\/. Accessed: July 1 2021."},{"key":"e_1_2_9_20_1","unstructured":"Communiqu\u00e9 commun MHEMO et Association fran\u00e7aise des h\u00e9mophiles (AFH) du 17 mars 2020:https:\/\/mhemo.fr\/wp\u2010content\/uploads\/2020\/03\/CP\u2010MHEMO\u2010AFH\u201013mars\u2010covid\u201019\u2010SARS\u2010Cov\u20102\u2010v12\u2010JH.pdf. Accessed: July 17 2021."},{"key":"e_1_2_9_21_1","unstructured":"Communiqu\u00e9 commun MHEMO et Association fran\u00e7aise des h\u00e9mophiles (AFH) du 17 mars 2020:https:\/\/mhemo.fr\/wp\u2010content\/uploads\/2020\/03\/MHEMO\u2010AFH\u201002\u201004.pdf. Accessed: July 17 2021."},{"key":"e_1_2_9_22_1","unstructured":"Communiqu\u00e9 commun MHEMO et Association fran\u00e7aise des h\u00e9mophiles (AFH) du 17 mars 2020:https:\/\/mhemo.fr\/wp\u2010content\/uploads\/2020\/03\/CP\u2010MHEMO\u2010AFH\u201014\u2010avril\u2010covid\u201019\u2010SARS\u2010Cov\u20102.pdf"},{"key":"e_1_2_9_23_1","unstructured":"Communiqu\u00e9 commun MHEMO et Association fran\u00e7aise des h\u00e9mophiles (AFH) du 17 mars 2020:https:\/\/mhemo.fr\/wp\u2010content\/uploads\/2020\/03\/CP\u2010MHEMO\u2010AFH\u201020\u2010avril\u2010covid\u201019.pdf. Accessed: July 17 2021."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13016"},{"issue":"79","key":"e_1_2_9_25_1","article-title":"Impact of the COVID\u201019 lockdown suffering from idiopathic interstitial pneumonia","volume":"16","author":"Beltramo G","year":"2021","journal-title":"Respir Med and Res"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.08.094"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-218360"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291702006074"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.06.042"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:38:37Z","timestamp":1692959917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/hae.14526"],"URL":"https:\/\/doi.org\/10.1111\/hae.14526","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]},"assertion":[{"value":"2021-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}