{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:53:39Z","timestamp":1793210019498,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Ankle arthropathy is highly prevalent among people with haemophilia (PwH), even with prophylaxis, and leads to pain and disability. Mechanisms and consequences of painful symptoms related to ankle arthropathy have not been extensively studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A consecutive sample of 30 adult PwH was included (60 ankles). Ankle structure was assessed with magnetic resonance imaging (IPSG\u2010MRI) and ultrasound (HEAD\u2010US). The HJHS 2.1 assessed function of ankles and knees. Physical functioning was assessed with the Timed Up and Go test, the 2\u2010Minute Walking Test and activity limitations with the HAL questionnaire. Health\u2010related quality of life was evaluated using the EQ\u20105D\u20105L questionnaire. Overall pain severity was examined using the Brief Pain Inventory questionnaire and ankle pain intensity with a visual analogue scale. Pressure pain thresholds with an algometer assessed pain sensitivity. Spearman correlations were used to calculate interrelations between joint structure, function and pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five PwH (83%) reported \u22651 painful joint, with 67% reporting the ankle as most painful joint. MRI\u2010confirmed abnormalities were seen in 76% of talocrural and 55% of subtalar joints. HEAD\u2010US abnormalities were seen in 93% of the ankles. A large variation was seen in pain sensitivity at the ankle. While moderate to high correlations were observed between ankle structure and HJHS, no meaningful correlations were found between MRI\u2010scores and pain intensity or sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Structural joint damage is present in many ankles but is not related to pain in PwH. Further studies should consider somatosensory nervous system dysfunction in PwH as contributing factor to painful ankle arthropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14544","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T21:44:07Z","timestamp":1647467047000},"page":"480-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gaining more insight into ankle pain in haemophilia: A study exploring pain, structural and functional evaluation of the ankle joint"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-878X","authenticated-orcid":false,"given":"Nathalie Anne","family":"Roussel","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences (MOVANT) University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-7112","authenticated-orcid":false,"given":"Val\u00e9rie\u2010Anne","family":"Chantrain","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences (MOVANT) University of Antwerp  Antwerp Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-9026","authenticated-orcid":false,"given":"Anthe","family":"Foubert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences (MOVANT) University of Antwerp  Antwerp Belgium"},{"name":"Pain in Motion International Research Group, 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Belgium"},{"name":"Pain in Motion International Research Group, www.paininmotion.be"},{"name":"Department of Rehabilitation Sciences and Physiotherapy Ghent University  Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Guillaume","sequence":"additional","affiliation":[{"name":"Department of Radiology Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3568-3254","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric","family":"Lecouvet","sequence":"additional","affiliation":[{"name":"Department of Radiology Cliniques Universitaires Saint\u2010Luc Universit\u00e9 Catholique de Louvain  Brussels 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