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However, these advances do not always easily translate into improved management for patients with VWD and low\u2010VWF levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>VWD and pregnancy<\/jats:title><jats:p>For example, the treatment of pregnant women with VWD both pre\u2010 and postpartum can be complicated. While knowledge of the <jats:italic>VWF<\/jats:italic> genotype at some amino acid positions can aid in knowledge of who may be at increased risk of thrombocytopenia or insufficient increase in VWF levels during pregnancy, in many cases, VWF levels and bleeding severity is highly heterogeneous, making monitoring recommended during pregnancy to optimize treatment strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>VWF and COVID\u201019<\/jats:title><jats:p>New challenges related to the consequences of dysregulation of hemostasis continue to be discovered. The ongoing COVID\u201019 pandemic has highlighted that VWF has additional biological roles in the regulation of inflammatory disorders and angiogenesis, disruption of which may contribute to COVID\u201019 induced vasculopathy. Increased endothelial cell activation and Weibel\u2010Palade body exocytosis in severe COVID\u201019 lead to markedly increased plasma VWF levels. Coupled with impairment of normal ADAMTS13 multimer regulation, these data suggest a role for VWF in the pathogenesis underlying pulmonary microvascular angiopathy in severe COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>With the increased affordability and availability of next\u2010generation sequencing techniques, as well as a push towards a multi\u2010omic approach and personalized medicine in human genetics, there is hope that translational research will improve VWD patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14547","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T06:07:08Z","timestamp":1651817228000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["von Willebrand disease and von Willebrand factor"],"prefix":"10.1111","volume":"28","author":[{"given":"Brooke","family":"Sadler","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Castaman","sequence":"additional","affiliation":[{"name":"Department of Oncology Center for Bleeding Disorders and Coagulation, Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"O'Donnell","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland  Dublin 2 Ireland"},{"name":"National Coagulation Centre St James's Hospital  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2008.01.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00933.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003265"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.03.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.036848"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018027813"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7933.2003.00592.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03541-8"},{"issue":"1","key":"e_1_2_7_11_1","first-page":"89","article-title":"Factor VIII and factor IX in a twin population. 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