{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:54:45Z","timestamp":1770742485370,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Osteoarthritis (OA) and haemophilic arthropathy (HA) are clinically similar, but pathologically distinct conditions which result in joint pain and loss of function. Distinguishing their disease mechanisms is therefore a key step in the development of curative therapy, as opposed to current symptomatic treatments. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 is a metzincin\u2010family member proteoglycan with known local involvement in OA pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the potential differences and discriminatory potential of ADAMTS\u20104 between OA and HA patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We determined ADAMTS\u20104 plasma concentrations by ELISA in patients with HA and OA. This pilot cross\u2010sectional study included <jats:italic>N<\/jats:italic>\u00a0=\u00a040 male participants equally divided across four subgroups: haemophilia patients with severe or mild HA and control subjects with severe or mild\/no OA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our study showed a striking elevation in plasma ADAMTS\u20104 expression levels in HA patients as compared to OA, as well as an increase in patients with severe as compared to mild HA. By performing the binomial logistical analysis and fitting the receiver\u2013operator curve (ROC) (cut\u2010off probability .5), ADAMTS\u20104 had a sensitivity of 95% and specificity of 50% in discriminating between HA and OA among our study participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Uncovering the marked differences in plasma levels of ADAMTS\u20104 in patients with HA versus OA potentially sheds new light on the mechanisms of HA pathogenesis and could foster more research into the roles ADAMTS\u20104 and other matrix metalloproteinases (MMPs) play in HA versus OA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14569","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T15:20:40Z","timestamp":1652196040000},"page":"656-662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["ADAMTS\u20104 as a possible distinguishing indicator between osteoarthritis and haemophilic arthropathy"],"prefix":"10.1111","volume":"28","author":[{"given":"Natasa","family":"Kalebota","sequence":"first","affiliation":[{"name":"Clinic for Rheumatic Diseases and Rehabilitation University Hospital Centre Zagreb  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-1646","authenticated-orcid":false,"given":"Grgur","family":"Salai","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb  Zagreb Croatia"},{"name":"Teaching Institute of Emergency Medicine of the City of Zagreb  Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Porin","family":"Peric","sequence":"additional","affiliation":[{"name":"Clinic for Rheumatic Diseases and Rehabilitation University Hospital Centre Zagreb  Zagreb Croatia"},{"name":"School of Medicine University of Zagreb  Zagreb 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