{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:11Z","timestamp":1787014271313,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Platelet function tests are used to screen and diagnose patients with possible inherited platelet function defects (IPFD). Some acquired platelet dysfunction may be caused by certain drugs or comorbidities, which need to be excluded before testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify current practice among centres performing platelet function tests in Northern Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 14 clinical centres from Sweden (six), Finland (two), Denmark (two), Norway (one), Estonia (two) and Iceland (one) completed the survey questionnaire, the population capture area of about 29.5 million.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six of the 14 (42.8%) centres providing platelet function assessment represent comprehensive treatment centres (EUHANET status). A Bleeding score (BS) or ISTH bleeding assessment tool (ISTH BAT score) is evaluated in 11\/14 (78.6%) centres and family history in all. Five\/14 centres (35.7%) use structured preanalytical patient instructions, and 10\/14 (71.4%) recorded questionnaire on the preassessment of avoidance of any drugs or natural products affecting platelet functions. Preliminary investigations of screening tests of coagulation are performed in 10\/14 (71.4%), while in 4\/14 (28.6%), the diagnostic work\u2010up of IPFD and von Willebrand disease (VWD) is performed simultaneously. The work\u2010up of IPFD includes peripheral blood smear in 10\/14 (71.4%), platelet aggregometry in all, flow cytometry in 10\/14 (71.4%) and Platelet Function Analysis (PFA) in 3\/11 (28.6%). Molecular genetic diagnosis is available in 7\/14 (50%) centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The considerable variability in the current practice illustrates the need for harmonization between the Northern European centres according to the international registers (i.e. EUHASS) and IPFD guidelines (ISTH, EHA).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14578","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T10:37:34Z","timestamp":1651747054000},"page":"642-648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Platelet function testing: Current practice among clinical centres in Northern Europe"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6564","authenticated-orcid":false,"given":"Timea","family":"Szanto","sequence":"first","affiliation":[{"name":"Coagulation Disorders Unit, Department of Hematology, Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1775-1727","authenticated-orcid":false,"given":"Eva","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine &amp; Centre for Thrombosis and Haemostasis Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Ramstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Department of Clinical and Experimental Medicine Link\u00f6ping University  Link\u00f6ping Sweden"},{"name":"School of Medical Sciences \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva B.","family":"Lein\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Haematology, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l A.","family":"Holme","sequence":"additional","affiliation":[{"name":"Department of Haematology Oslo University Hospital and Institute of Clinical Medicine, University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovan P.","family":"Antovic","sequence":"additional","affiliation":[{"name":"Coagulation Research, Institute for Molecular Medicine and Surgery, Karolinska Institute &amp; Department of Clinical Chemistry Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta","family":"Holmstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Health and Department of Acute Internal Medicine and Geriatrics Medicine and Caring Sciences Link\u00f6ping University  Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pall T.","family":"Onundarson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Iceland  Reykjavik Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Pikta","sequence":"additional","affiliation":[{"name":"Laboratory North Estonia Medical Centre  Tallinn Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Vaide","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology University of Tartu, Institute of Clinical Medicine  Tartu Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-4880","authenticated-orcid":false,"given":"Anna","family":"Olsson","sequence":"additional","affiliation":[{"name":"Region V\u00e4stra G\u00f6taland, Department of Medicine Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Haematology and Coagulation Disorders Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"K\u00e4rkk\u00e4inen","sequence":"additional","affiliation":[{"name":"Hemostasis and Platelet Laboratory Fimlab Laboratoriot  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Bitar","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Chemistry, Faculty 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