{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:13:49Z","timestamp":1773029629255,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Haemophilia has substantial SD effects on health\u2010related quality of life (HRQoL), particularly for people with severe haemophilia. How certain aspects of haemophilia influence HRQoL is not well understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop predictive models of variables influencing HRQoL in people with severe haemophilia A or B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from 514 participants with haemophilia A or B who provided EQ\u20105D\u20103L responses in the 2015 CHESS study. Treatment was categorized as always been on\u2010demand (POD), previously on prophylaxis and moved to on\u2010demand regimen (SOD), on prophylaxis from diagnosis (PX), and prophylaxis, previously on\u2010demand (PXOD). Target joints were defined as \u2018locations of chronic synovitis\u2019 as reported by the treating physician. Regression models were evaluated to assess the impact of demographic and clinical covariates on HRQoL scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant covariates were generally consistent across models, with number of target joints, number of hospital admissions, and any haemophilia treatment regimen other than PX all independently negatively impacting estimated EQ\u20105D score. Higher level of treatment adherence (high vs. low\/medium) and use of a prophylaxis treatment regimen had positive effects on estimated EQ\u20105D scores. Target joints were associated with a 0.04 decrement in EQ\u20105D score, and high versus low\/medium adherence was associated with a 0.06 increment. PXOD, POD, and SOD treatment regimens were associated with decrements in predicted scores of 0.07, 0.09, and 0.08, respectively, versus PX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides a model to estimate the impact of haemophilia interventions on HRQoL, to help assess the relative impact on patient\u2010centric outcomes for this lifelong condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14583","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T19:53:26Z","timestamp":1652212406000},"page":"796-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Examining the impact of haemophilia treatment on health\u2010related quality of life"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-0131","authenticated-orcid":false,"given":"Anum","family":"Shaikh","sequence":"first","affiliation":[{"name":"HCD Economics  Daresbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Pedra","sequence":"additional","affiliation":[{"name":"HCD Economics  Daresbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Cawson","sequence":"additional","affiliation":[{"name":"HCD Economics  Daresbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Wiseman","sequence":"additional","affiliation":[{"name":"Swedish Orphan Biovitrum Ltd.  Cambridgeshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13166"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S212723"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13214"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14072"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S139851"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13546"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12759"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0660-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12672"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4733.2002.54128.x"},{"key":"e_1_2_9_13_1","first-page":"190","article-title":"The relationship between body mass index and health\u2010related quality of life","author":"Macran S","year":"2004","journal-title":"Working Papers"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803365"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-018-0908-9"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:43:11Z","timestamp":1692693791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/hae.14583"],"URL":"https:\/\/doi.org\/10.1111\/hae.14583","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"2021-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}