{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:01:43Z","timestamp":1782302503839,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prophylactic treatment is the gold standard in the treatment of patients with haemophilia. Prophylaxis with extended half\u2010life (EHL) treatment has shown long\u2010term safety and efficacy in patients with haemophilia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of prophylaxis with EHL treatment in the frequency of haemarthrosis and musculoskeletal health in adult patients with severe haemophilia A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective cohort study. Forty\u2010six patients with severe haemophilia A were recruited. The frequency of haemarthrosis (self\u2010reports), joint condition (<jats:italic>Haemophilia Joint Health Score<\/jats:italic>), pain intensity (visual analogue scale), range of motion (goniometry), and strength (dynamometry) and muscle activation (surface electromyography) were evaluated. Three assessments were carried out: at baseline (T0), at 6\u00a0months (T1) and at 12 months following treatment (T2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant changes in the within\u2010subject effect in the frequency of haemarthrosis in elbow (F(1.05;96.20) = 3.95; <jats:italic>P<\/jats:italic> &lt; .001) and knee (F(1.73;157.99) = 9.96; <jats:italic>P<\/jats:italic> &lt; .001). Significant within\u2010subject effect in elbow pain intensity (F(2;182) = 63.51; <jats:italic>P<\/jats:italic> &lt; .001) was found. The mean values of the frequency haemarthrosis in elbow (from .66\u00b11.01 to .04\u00b1.20) and knees (from .55\u00b1.68 to .33\u00b1.53) decrease after the period study. The intensity of elbow pain and (from 3.08\u00b11.69 to 2.67\u00b11.73), decrease after the 12\u2010month follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylaxis with extended half\u2010life treatment reduces the frequency of haemarthrosis in elbow and knee in adult patients with haemophilia. EHL treatment reduces the intensity of elbow pain in patients with haemophilic arthropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14592","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T19:57:47Z","timestamp":1652471867000},"page":"857-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["LongHest project: A prospective, observational study of extended half\u2010life treatment in the musculoskeletal health of patients with severe haemophilia A"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4276-6982","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Cuesta\u2010Barriuso","sequence":"first","affiliation":[{"name":"Department of Surgery and Medical\u2010Surgical Specialties, Faculty of Medicine University of Oviedo  Oviedo Spain"},{"name":"Royal Victoria Eugenia Foundation  Madrid 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