{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:53:23Z","timestamp":1778932403162,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Clarifying the links between iron and FGF23, SOX9 expression in chondrocytes would be helpful for comprehending articular cartilage degradation pathogenesis in blood\u2010induced arthritis and exploring new protective methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to determine iron regulation of fibroblast growth factor 23 (FGF23) and SRY\u2010box 9 (SOX9) in human chondrocytes, an area which is unexplored in blood\u2010induced arthritis cartilage degradation pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Expression of FGF23, SOX9, MMP13 and collagen \u2161 in articular cartilage of patients with osteoarthritis (OA) or haemophilic arthritis (HA) was determined by western blot (WB). Iron\u2010induced FGF23 and SOX9 mRNA and protein expression in primary human normal chondrocyte cells (HUM\u2010iCell\u2010s018) was quantified by qRT\u2010PCR and WB, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that compared with OA patients, the expression of FGF23, MMP13 in articular cartilage of patients with HA was up\u2010regulated, while the expression of SOX9, collagen \u2161 was down\u2010regulated. Iron\u2010induced FGF23 and suppressed SOX9 expression in chondrocytes in a dose\u2010dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrated that iron was involved in hemophilic cartilage lesion directly via changing cartilage phenotype through regulation of FGF23 and SOX9 expression in chondrocytes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14623","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T14:18:07Z","timestamp":1657289887000},"page":"1062-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["FGF23 and SOX9 expression in haemophilic cartilage: In vitro studies of the effects of iron"],"prefix":"10.1111","volume":"28","author":[{"given":"Liujie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery Puai Hospital Tongji Medical College Huazhong University of Science 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