{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:43:15Z","timestamp":1790772195772,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Emicizumab prophylaxis significantly reduces bleeding events; however, the associated impact on bone\/joint health is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the effect of emicizumab prophylaxis on bone\/joint health in people with haemophilia A (PwHA) without FVIII inhibitors enrolled in HAVEN 3 (NCT02847637).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Haemophilia joint health scores (HJHS; v2.1) were evaluated at baseline and Weeks 49 and 97 in PwHA receiving emicizumab (<jats:italic>n<\/jats:italic>\u00a0=\u00a0134), and at baseline and Weeks 49, 73 and 97 in PwHA who switched to emicizumab after 24\u00a0weeks of no prophylaxis (<jats:italic>n<\/jats:italic>\u00a0=\u00a017). Bone and joint biomarkers were measured in 117 PwHA at baseline and at Weeks 13, 25, 49 and 73.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HJHS was lower for PwHA who were previously on FVIII prophylaxis, aged\u00a0&lt;40 years or had no target joints at baseline compared with PwHA who were receiving no prophylaxis, aged \u226540 years or with target joints. Clinically significant mean (95% confidence interval) improvements from baseline of \u22122.13 (\u22123.96, \u2212.29) in HJHS joint\u2010specific domains were observed at Week 49 in PwHA with at least one target joint at study entry (<jats:italic>n<\/jats:italic>\u00a0=\u00a071); these changes were maintained through Week 97. Improvements in HJHS from baseline were also observed for PwHA aged 12\u201339 years. Biomarkers of bone resorption\/formation, cartilage degradation\/synthesis, and inflammation did not change significantly during emicizumab prophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinically relevant improvements in HJHS were observed in younger PwHA and those with target joints after 48\u00a0weeks of emicizumab in HAVEN 3. Biomarkers of bone\/joint health did not show significant changes during 72\u00a0weeks of emicizumab prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14642","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T18:08:28Z","timestamp":1659118108000},"page":"1033-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effect of emicizumab prophylaxis on bone and joint health markers in people with haemophilia A without factor VIII inhibitors in the HAVEN 3 study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-9649","authenticated-orcid":false,"given":"Anna","family":"Kiialainen","sequence":"first","affiliation":[{"name":"F. Hoffmann\u2010La Roche Ltd  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Niggli","sequence":"additional","affiliation":[{"name":"F. 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South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Paz\u2010Priel","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"},{"name":"Spark Therapeutics, Inc.  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne I.","family":"Adamkewicz","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gallia G.","family":"Levy","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco California USA"},{"name":"Graphite Bio, Inc.  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