{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:33:38Z","timestamp":1787502818154,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Exercise capacity has been established as a protective factor against joint impairment in people with haemophilia (PWH). However, little is known about how exercise capacity is affected in PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To analyse exercise capacity, as assessed by standardised laboratory or field tests in PWH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted to identify manuscripts investigating physical capacity in PWH. An electronic search of PubMed\/MEDLINE, Embase, Web of Science, CENTRAL and CINAHL was conducted from inception to 13 April, 2022. Two independent reviewers performed data extraction and assessed study quality using the critical appraisal tools of the Joanna Briggs Institute.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nineteen studies with 825 patients were included. Most studies used the six\u2010min walk test (6MWT) or peak\/maximal oxygen consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      max). In children, the distance walked ranged from 274\u00a0\u00b1\u00a036.02 to 680\u00a0\u00b1\u00a0100\u00a0m. In adults, the distance walked ranged from 457.5\u00a0\u00b1\u00a096.9 to 650.9\u00a0\u00b1\u00a0180.3\u00a0m. VO\n                      <jats:sub>2<\/jats:sub>\n                      max ranged from 37\u00a0\u00b1\u00a08 to 47.42\u00a0\u00b1\u00a08.29\u00a0ml kg\n                      <jats:sup>\u20131<\/jats:sup>\n                      \u00a0min\n                      <jats:sup>\u20131<\/jats:sup>\n                      . Most studies reported lower values of exercise capacity compared to standardised values. Overall, the quality of the studies was moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Most of the studies showed that PWH have lower exercise capacity compared to reference values of 6MWT or VO\n                      <jats:sub>2<\/jats:sub>\n                      max. Based on these results, it is necessary to emphasise in both the promotion and the prescription of physical exercise in PWH.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14646","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T16:14:01Z","timestamp":1658938441000},"page":"891-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Exercise capacity in people with haemophilia: A systematic review"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-3368","authenticated-orcid":false,"given":"Carlos","family":"Cruz\u2010Montecinos","sequence":"first","affiliation":[{"name":"Departament of Physical Therapy Faculty of Medicine University of Chile  Santiago Chile"},{"name":"Department of Physiotherapy Physiotherapy in Motion Multispeciality Research Group (PTinMOTION) University of Valencia  Valencia 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