{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T13:16:58Z","timestamp":1788959818086,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Increased survival among men with haemophilia has brought with it an increased risk of age\u2010related comorbidities that may be challenging to treat in the presence of a bleeding disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Estimate the prevalence of several age\u2010related comorbidities among older males with haemophilia receiving care in the U.S. haemophilia treatment center (HTC) network compared to that among the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People with bleeding disorders who receive care in network HTCs can volunteer to participate in a surveillance registry that collects detailed clinical information including the presence of comorbid conditions at annual visits. We used registry data collected on males with haemophilia age 45 years and older to calculate lifetime prevalence of obesity, diabetes, hypertension, cardiovascular disease, renal disease, cancer, anxiety and depression. Comparable data on the U.S. general male population was obtained from the National Health Interview Survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the surveillance period, 1592 middle\u2010aged (45\u201364 years) and 645 older (\u226565 years) patients with haemophilia had comorbidity data collected during 6435 HTC visits. Most haemophilia patients in both age groups had a higher prevalence of anxiety, depression and diabetes, but a lower prevalence of hypertension, coronary heart disease, stroke and myocardial infarction compared to the general U.S. male population. In addition, middle\u2010aged patients had lower rates of leukemia, whereas older patients had higher rates of obesity than the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings highlight the mental stress associated with this chronic condition and support continued public health obesity prevention efforts in the haemophilia community.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14647","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T11:33:41Z","timestamp":1659612821000},"page":"986-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of comorbid conditions among older males with haemophilia receiving care in haemophilia treatment centers in the United States"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-6824","authenticated-orcid":false,"given":"J. Michael","family":"Soucie","sequence":"first","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"Synergy America, Inc.  Duluth Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binh","family":"Le","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandi","family":"Dupervil","sequence":"additional","affiliation":[{"name":"Division of Blood Disorders Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline N.","family":"Poston","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine and Division of Clinical Pathology Department of Pathology Larner College of Medicine at the University of Vermont  Burlington Vermont USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050435"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2015.10.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03201.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03318.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25076"},{"key":"e_1_2_9_7_1","unstructured":"National Center for Health Statistics. 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