{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:10:56Z","timestamp":1790349056856,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Majority of haemophilia A patients in our comprehensive care centre have switched from standard half\u2010life (SHL) to extended half\u2010life (EHL) FVIII products in a short time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We compared the clinical and laboratory outcomes between SHL and EHL FVIII prophylaxis in product switchers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective inception cohort of all adult haemophilia A patients switched to EHL (rFVIIIFc or rFVIII\u2010PEG) prophylaxis in our centre. Dosing, product utilization, annualized bleed rates (ABR), treatment regimen and pharmacokinetics by Web Accessible Population Pharmacokinetic Service (WAPPS)\u2010Hemo were compared between SHL and EHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 38 patients, whose median age was 38 years (range 17\u201375). Median FVIII dose was 23\u00a0IU\/kg for SHL versus 25\u00a0IU\/kg for EHL. After switching, weekly infusions decreased by 29% from median 2.8 (every 2.5 days) to 2.0 (every 3.5 days) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0&lt;.001) and factor consumption for prophylaxis by 17% from 60 to 50\u00a0IU\/kg\/week (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0&lt;.001). Weekly infusions decreased in 71% and FVIII utilization in 55% of patients. ABR remained low (1.0 for SHL and .5 for EHL, respectively). In pharmacokinetics, the half\u2010life of FVIII increased from median 13 to 21\u00a0h after switching. Times above .01 and .03\u00a0IU\/ml improved from 85 to 131\u00a0h and from 65 to 106\u00a0h. Half\u2010lives of the SHL products and von Willebrand factor levels predicted half\u2010lives with the EHL products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our cohort study confirms the successful experience of switching to EHL FVIII products, with decreased infusion frequency, factor consumption and excellent clinical efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/hae.14649","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T14:33:55Z","timestamp":1659969235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Switching from standard to extended half\u2010life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5134-7288","authenticated-orcid":false,"given":"Vuokko","family":"Nummi","sequence":"first","affiliation":[{"name":"Department of Hematology Coagulation Disorders Unit Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Elina","family":"Lehtinen","sequence":"additional","affiliation":[{"name":"Department of Hematology Coagulation Disorders Unit Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Health Research Methods Evidence and Impact McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-6564","authenticated-orcid":false,"given":"Timea","family":"Szanto","sequence":"additional","affiliation":[{"name":"Department of Hematology Coagulation Disorders Unit Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-3094","authenticated-orcid":false,"given":"Riitta","family":"Lassila","sequence":"additional","affiliation":[{"name":"Department of Hematology Coagulation Disorders Unit Comprehensive Cancer Center Helsinki University Hospital  Helsinki Finland"},{"name":"Research Program in Systems Oncology Faculty of Medicine Helsinki University  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1997.130135000.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13811"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13298"},{"key":"e_1_2_10_5_1","first-page":"CD014201","article-title":"Clotting factor concentrates for preventing bleeding and bleeding\u2010related complications in previously treated individuals with haemophilia A or B","volume":"8","author":"Olasupo OO","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2001.00534.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1571315"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02383.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13616"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-09-382846"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-630897"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14469"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13946"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2022.103678"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13834"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13970"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"374","article-title":"Optimising prophylaxis outcomes and costs in haemophilia patients switching to recombinant FVIII\u2010Fc: a single\u2010centre real\u2010world experience","volume":"18","author":"Tagliaferri A","year":"2020","journal-title":"Blood Transfus"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13432"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14369"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12601"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.6558"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13160"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05325.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-360594"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.11.016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1598058"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14394"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14784"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12296"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12421"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13001"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14649","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14649","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14649","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T05:48:08Z","timestamp":1692510488000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,8]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/hae.14649"],"URL":"https:\/\/doi.org\/10.1111\/hae.14649","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,8]]},"assertion":[{"value":"2022-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}