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Compared to controls, PwMSH were significantly less active in moderate and vigorous PA parameters (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and less physically fit indicated by 6\u2010Minute Walk distance (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0005), grip strength (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.040) and balance (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0005). PwMSH had higher rates of abdominal adiposity compared to controls measured by waist circumference indices (all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Resting blood pressure and arterial stiffness were not significantly different (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.797 and .818, respectively). With respect to overall PA, World Health Organisation recommended targets for adults were achieved by the majority of both groups (haemophilia: 72.9% vs. controls: 90.0%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.069). Importantly, the number of PwMSH who achieved guideline recommended PA via longer, sustained bouts of moderate\u2013vigorous PA was significantly lower compared to controls (18.8% vs. 56.7%; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). Lastly, clinically diagnosed hypertension, insulin resistance and hyperlipidaemia were more prevalent amongst PwMSH compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low levels of PA and physical fitness, and significant rates of abdominal adiposity and hypertension may collectively influence the risk and severity of various cardiometabolic and\/or musculoskeletal health issues amongst ageing PwMSH. Personalised multi\u2010disciplinary health interventions involving PA, dietary and health psychology input for PwMSH warrant future investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14653","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T22:43:51Z","timestamp":1664923431000},"page":"72-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Physical activity, physical fitness and cardiometabolic risk amongst adults with moderate and severe haemophilia"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-8022","authenticated-orcid":false,"given":"Megan","family":"Kennedy","sequence":"first","affiliation":[{"name":"Discipline of Physiotherapy Trinity Centre for Health Sciences Trinity College Dublin St. James's Hospital  Dublin 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