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A total of 549 people with moderate HA were treated with factor replacement prophylaxis and were from high\u2010income countries. On the contrary, nearly all people with mild HA received desmopressin (<jats:italic>n<\/jats:italic>\u00a0=\u00a0599). Details of treatment regimens for women with haemophilia and people with HB were sparse. Three studies provided long\u2010term outcomes for people with moderate haemophilia who received prophylaxis with factor concentrate, supporting early prophylaxis in people with a frequent bleeding phenotype regardless of their endogenous clotting factor level to preserve joint health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There remain large knowledge gaps when considering how to provide optimal treatment for people with non\u2010severe haemophilia. Nonetheless, there is a strong rationale that prophylaxis should be considered early in life according to similar strategies as for severe haemophilia for those with a frequent severe bleeding phenotype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14676","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T03:40:15Z","timestamp":1665632415000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prophylaxis use of clotting factor replacement products in people with non\u2010severe haemophilia: A review of the literature"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-8766","authenticated-orcid":false,"given":"Alfonso","family":"Iorio","sequence":"first","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Hamilton\u2010Niagara Hemophilia Program  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"K\u00f6nigs","sequence":"additional","affiliation":[{"name":"Clinical and Molecular Hemostasis University Hospital Frankfurt, Goethe University, Department of Paediatrics  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-2806","authenticated-orcid":false,"given":"Mark T.","family":"Reding","sequence":"additional","affiliation":[{"name":"Center for Bleeding and Clotting Disorders University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Rotellini","sequence":"additional","affiliation":[{"name":"National Hemophilia Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0934-0680","authenticated-orcid":false,"given":"Mark W","family":"Skinner","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence and Impact McMaster University  Hamilton Ontario Canada"},{"name":"Institute for Policy Advancement, Ltd.  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