{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:54:23Z","timestamp":1778910863811,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["21635"],"award-info":[{"award-number":["21635"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The use of virtual interventions is of interest to patients with chronic disease and healthcare professionals. This study aimed to determine the effect of virtual child disease management programme on burden and social adjustment of caregivers of children with coagulation factor deficiencies. Moreover, the effect of this intervention on children's acute pain and bleeds was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This clinical trial was conducted on 80 caregivers of children with coagulation factor deficiencies. The subjects were randomly assigned into the intervention and control groups. A comprehensive virtual child disease management programme was conducted for 8\u00a0weeks and caregiver\u2019 burden and their social adjustment were assessed with the HEMOCAB and social adjustment subscale of Bell Adjustment Inventory, respectively. Data were analysed using ANCOVA and Wilcoxon test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before the intervention, both groups were similar regarding the caregivers\u2019 burden and social adjustment and children's acute pain and bleeds. However, a significant difference was observed between groups in concern to caregivers\u2019 burden (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), women's and men's social adjustment (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03), and children's acute pain and bleeds (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) after the virtual disease management programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that using a virtual child disease management programme reduced burden and improved social adjustment of caregivers of children with coagulation factor deficiencies. This intervention decreased frequencies of acute pain and bleeds in children. Therefore, using this effective intervention in clinical practice is warranted to decrease the caregivers\u2019 burden as well as acute pain and bleeds in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14678","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T13:59:48Z","timestamp":1666274388000},"page":"199-209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of a virtual child disease management programme on burden and social adjustment of caregivers of children with coagulation factor deficiencies"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7334-9364","authenticated-orcid":false,"given":"Masoume","family":"Rambod","sequence":"first","affiliation":[{"name":"Community Based Psychiatric Care Research Center, Nursing and Midwifery School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilofar","family":"Pasyar","sequence":"additional","affiliation":[{"name":"Community Based Psychiatric Care Research Center, Nursing and Midwifery School Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Irannejad Parizi","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Edraki","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-5958","authenticated-orcid":false,"given":"Kate","family":"Khair","sequence":"additional","affiliation":[{"name":"Haemnet  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-0478","authenticated-orcid":false,"given":"Sylvia","family":"von Mackensen","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,20]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"871","article-title":"A Cross\u2010National Survey of People Living with Haemophilia: impact on Daily Living and Patient Education in Central Europe","volume":"15","author":"Banchev A","year":"2021","journal-title":"Pat Pref Adher"},{"issue":"8","key":"e_1_2_11_3_1","article-title":"Social participation and haemophilia: self\u2010perception, social support, and their influence on boys in Canada","volume":"5","author":"Chiu AS","year":"2021","journal-title":"Thromb Haemostasis"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.17225\/jhp00075"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13826"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13684"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13736"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.15003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12471"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecresq.2015.05.003"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.invent.2021.100382"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02689.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.711973"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/SHTT.S40961"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13186"},{"key":"e_1_2_11_16_1","unstructured":"Create a randomisation list. 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