{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:22:32Z","timestamp":1773044552335,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Improvements in treatment strategies have led to increased life expectancy of persons with haemophilia (PWH). Consequently, age\u2010related comorbidities become increasingly relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the prevalence of age\u2010related comorbidities, mortality, health service utilisation and predictors of hospitalisation in PWH compared to the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a population\u2010based retrospective cohort study using linked administrative data. Men with haemophilia were identified in Alberta, Canada (2012\u20132019) with a validated case definition and were age\u2010matched with male population controls. We calculated the prevalence of major comorbidities, all\u2010cause mortality, and examined health service utilisation including Emergency Department visits and hospitalisations. Logistic regression was applied to identify predictors of hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 198 and 329 persons with moderately severe haemophilia and mild\/moderate, respectively. Moderately severe haemophilia had a higher risk of death (standardised mortality ratio 3.2, 95% confidence interval [CI] 1.4\u20136.3) compared to the general population. PWH had a significantly higher prevalence of hypertension, liver diseases and malignancies than controls. Moderately severe haemophilia was associated with significantly higher rates of hospitalisations (52.5% vs. 14.5%), Emergency Department visits (89.1% vs. 62.7%) and intensive care admissions (8.9% vs. 2.3%). Age\u00a0&gt;\u00a065 years (adjusted odds ratio [aOR] 6.8) and presence of multiple comorbidities (aOR 3.9) were significant predictors of hospitalisations among PWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite advanced care, haemophilia is associated with higher acute care utilisation than the general population, highlighting the substantial burden of illness on patients and the health care system.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14680","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T14:05:04Z","timestamp":1666274704000},"page":"219-229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increased acute care utilisation, comorbidities and mortality in adults with haemophilia: A population\u2010based cohort study from 2012 to 2019"],"prefix":"10.1111","volume":"29","author":[{"given":"Arafat Ul","family":"Alam","sequence":"first","affiliation":[{"name":"Department of Medicine University of Alberta  Edmonton Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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