{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:11:13Z","timestamp":1747185073501,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Children with haemophilia (CwH) have lower bone mineral density in the spine (trabecular bone) than healthy children. There are few studies focusing on bone mineral density in long bones (cortical bone).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate bi\u2010laterally the distal third of radius and midshaft tibias using quantitative ultrasound (QUS) and assess the speed of sound (SoS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study where 91 CwH and 91 age\u2010matched healthy boys were included. Joint evaluation was determined with the Haemophilia Joint Health Score 2.1 and SoS values. The Z scores were measured with the Sunlight Omnisense 8000 S equipment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010one CwH (haemophilia A) were evaluated (26 mild form, 26 moderate, and 39 severe). Most patients were treated with on\u2010demand factor replacement and had higher total HJHS scores according to severity (4.8, 14.8 and 14.1, respectively). Patients with moderate and severe disease showed a statistical difference in SoS values for both radius and tibias compared to controls. QUS Z\u2010scores \u2265\u20102 were more frequent in radius and tibias in CwH, but were statistically significant only in tibias when compared to controls (in 30% mild, 46% moderate, 28% severe, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was diminished cortical bone density in radius and tibias of CwH compared to healthy controls. Changes predominated in tibias, more frequently affected according to the severity of haemophilia. Early intervention with factor replacement combined with physical activity are key aspects to promote bone health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14682","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T03:35:01Z","timestamp":1666064101000},"page":"274-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diminished cortical bone density of long bones among children with haemophilic arthropathy"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-7189","authenticated-orcid":false,"given":"Alberto","family":"Tlacuilo\u2010Parra","sequence":"first","affiliation":[{"name":"Medical Research Division. UMAE Hospital de Pediatria Centro M\u00e9dico Nacional de Occidente IMSS  Guadalajara M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Soto\u2010Padilla","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Department. UMAE Hospital de Pediatria Centro M\u00e9dico Nacional de Occidente IMSS  Guadalajara M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Toro\u2010Castro","sequence":"additional","affiliation":[{"name":"Pediatric Hematology Department. UMAE Hospital de Pediatria Centro M\u00e9dico Nacional de Occidente IMSS  Guadalajara M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Gutierrez\u2010Hermosillo","sequence":"additional","affiliation":[{"name":"Medical Research Division. UMAE Hospital de Pediatria Centro M\u00e9dico Nacional de Occidente IMSS  Guadalajara M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Guevara\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Dermatology Department. Instituto Dermatologico de Jalisco Secretaria de Salud Jalisco  Zapopan M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13449"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0629"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2773-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2017.22.1.1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-2173"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2017.06.018"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13697130802178471"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181e8cd40"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2010.02385.x"},{"volume-title":"Fetus into man: physical growth from conception to maturity","year":"1990","author":"Tanner JM","key":"e_1_2_9_11_1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocd.2013.11.002"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20353"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13631"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02700.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13951"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2005.01116.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14099"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12529"},{"issue":"2","key":"e_1_2_9_20_1","first-page":"82","article-title":"Osteoporosis\/osteopenia and hemophilic arthropathy in severely hemophilic patients","volume":"15","author":"Naderi A","year":"2012","journal-title":"Arch Iran Med"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02880.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02616.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13591"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15444"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-602060"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100041\u20101735964"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12515"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001759"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12736"},{"issue":"12","key":"e_1_2_9_30_1","article-title":"Exercise for haemophilia","volume":"12","author":"Strike K","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14540"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.06.034"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14423"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14682","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T22:15:13Z","timestamp":1692310513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,17]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/hae.14682"],"URL":"https:\/\/doi.org\/10.1111\/hae.14682","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"type":"print","value":"1351-8216"},{"type":"electronic","value":"1365-2516"}],"subject":[],"published":{"date-parts":[[2022,10,17]]},"assertion":[{"value":"2022-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}