{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:36:01Z","timestamp":1774409761880,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Reproductive\u2010age women with bleeding disorders (BDs) are underdiagnosed and understudied, despite their increased risk for adverse health outcomes and pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study examines pregnancy outcomes and obstetric complications of Utah women with BDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study utilized linked birth records and clinical billing data from two large Utah healthcare systems. Utah residents who had their first birth at\u00a0&gt;\u00a020\u00a0weeks gestation (2008\u20132015) and who received non\u2010emergent care within either system before delivery were included (<jats:italic>n<\/jats:italic>\u00a0=\u00a061 226). Multivariable logistic regression models were used to examine relationships between BDs and neonatal and obstetric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 295 women (.48%) were included in the BD study population. Women with BDs had significantly increased odds of preterm birth (aOR 1.85, 95% CI 1.32\u20132.60), Caesarean delivery (aOR 1.38, 95% CI 1.06\u20131.79), postpartum blood transfusion (aOR 2.55, 95% CI 1.05\u20136.22), unplanned postpartum hysterectomy (aOR 33.96, 95% CI 7.30\u2013157.89) and transfer to an intensive care unit (aOR 18.18, 95% CI 7.17\u201346.08). All of the women with BDs who experienced these serious complications were not diagnosed with a BD until the year of their first birth. Additionally, those with BDs were more likely to experience maternal and infant mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with BDs had an increased risk for preterm birth, Caesarean delivery, blood transfusion, unplanned hysterectomy, intensive care unit admission, maternal and infant mortality. Those who were not diagnosed with a BD before the year of their first birth were at an increased risk for serious pregnancy complications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14688","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T23:52:20Z","timestamp":1668729140000},"page":"240-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pregnancy and childbirth in women with bleeding disorders: A retrospective cohort study"],"prefix":"10.1111","volume":"29","author":[{"given":"Ashli","family":"Young","sequence":"first","affiliation":[{"name":"University of Utah Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-3387","authenticated-orcid":false,"given":"Ming Y.","family":"Lim","sequence":"additional","affiliation":[{"name":"Division of Hematology and Hematologic Malignancies, Department of Internal Medicine University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4487-1997","authenticated-orcid":false,"given":"Jessica","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Utah School of Medicine  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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