{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:59:22Z","timestamp":1766087962413},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T00:00:00Z","timestamp":1668643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Regular physiotherapy with a physiotherapist experienced in the field is not feasible for many patients with haemophilia. We, therefore, developed a blended physiotherapy intervention for persons with haemophilic arthropathy (HA) (e\u2010Exercise HA), integrating face\u2010to\u2010face physiotherapy with a smartphone application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to determine proof of concept of e\u2010 Exercise HA and to evaluate feasibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Proof of concept was evaluated by a single\u2010case multiple baseline design. Physical activity (PA) was measured with an accelerometer during a baseline, intervention and post\u2010intervention phase and analysed using visual inspection and a single case randomisation test. Changes in limitations in activities (Haemophilia Activities List [HAL]) and a General Perceived Effect (GPE) were evaluated between baseline (T0), post\u2010intervention (T1) and 3 months post\u2010intervention (T2) using Wilcoxson signed rank test. Feasibility was evaluated by the number of adverse events, attended sessions and open\u2010ended questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients with HA (90% severe, median age 57.5 (quartiles 50.5\u201363.3) and median HJHS 32 (quartiles 22\u201336)) were included. PA increased in two patients. HAL increased mean 15 (SD 9) points (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) at T1, and decrease to mean +8 points (SD 7) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.012) at T2 compared to T0. At T1 and T2 8\/9 participants scored a GPE\u00a0&gt;\u00a03. Median 5 (range 4\u20137) face\u2010to\u2010face sessions were attended and a median 8 out of 12 information modules were viewed. No intervention\u2010related bleeds were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A blended physiotherapy intervention is feasible for persons with HA and the first indication of the effectiveness of the intervention in decreasing limitations in activities was observed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14690","type":"journal-article","created":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T23:53:00Z","timestamp":1668729180000},"page":"290-307","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proof of concept and feasibility of a blended physiotherapy intervention for persons with haemophilic arthropathy"],"prefix":"10.1111","volume":"29","author":[{"given":"Merel A.","family":"Timmer","sequence":"first","affiliation":[{"name":"Van Creveldkliniek, Center for Benign Haematology, Thrombosis and Haemostasis, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"},{"name":"Physical Therapy Research, Department of Rehabilitation, Physical Therapy Science and Sport, Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht University  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isolde A. R.","family":"Kuijlaars","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Center for Benign Haematology, Thrombosis and Haemostasis, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corelien","family":"Kloek","sequence":"additional","affiliation":[{"name":"Research Group Innovation of Human Movement Care University of Applied Sciences Utrecht  Utrecht the Netherlands"},{"name":"Center for Physical Therapy Research and Innovation in Primary Care Julius Health Care Centers  Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piet","family":"de Kleijn","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek, Center for Benign Haematology, Thrombosis and Haemostasis, University Medical Center Utrecht Utrecht University  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger E. 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