{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:27:14Z","timestamp":1783798034918,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T00:00:00Z","timestamp":1673308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Previous studies show contradictory outcomes regarding dental, gingival and periodontal status in persons with haemophilia (PWH) compared to healthy controls. PWH may experience disease\u2010specific barriers to access dental care due to their bleeding tendency, which may lead to delays in oral care and severe dental problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the current subjective and objective oral health status in adult PWH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomly selected PWH of the Erasmus MC Haemophilia Treatment Center (HTC), Rotterdam, the Netherlands, were invited to participate. Data was collected using the Oral Health Impact Profile (OHIP\u201014NL) and personal interviews. A dentist used the DMFT index, the Dutch Periodontal Screening index (DPSI), plaque and bleeding index to score the dental status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight adult PWH were included in this study, 20 mild, 15 moderate\u2010severe and 13 severe haemophilia with a mean age of 44.7. PWH scored low on the OHIP\u201014 questionnaire (median total score 1.0; IQR .0\u20133.0), indicating a high self\u2010rating oral health status. The number of bleeding events, bleeding\u2010 and plaque index score was not statistically significant between patients with mild, moderate or severe haemophilia. The mean number of decayed, missing, and filled teeth (DMFT\u2010score) was significantly lower in the group of patients with severe haemophilia (median 2.0) compared to mild haemophilia (median 16.0) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). Twenty\u2010five patients (52.1%) reported to have encountered bleeding problems during or after dental interventions during their lifetime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dutch adult PWH A\/B have good dental status and oral health status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14719","type":"journal-article","created":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T17:49:55Z","timestamp":1673372995000},"page":"466-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The state of oral health in patients with haemophilia in the Netherlands"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2278-3459","authenticated-orcid":false,"given":"Greta","family":"Mulders","sequence":"first","affiliation":[{"name":"Department of Hematology Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-0761","authenticated-orcid":false,"given":"Hanneke","family":"van Verseveld","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Special Dental, Care Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5766-054X","authenticated-orcid":false,"given":"Joyce","family":"van der Geer","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Special Dental, Care Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5159-3497","authenticated-orcid":false,"given":"Eppo","family":"Wolvius","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Special Dental, Care Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5677-1371","authenticated-orcid":false,"given":"Frank","family":"Leebeek","sequence":"additional","affiliation":[{"name":"Department of Hematology Erasmus MC Erasmus University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.14046"},{"key":"e_1_2_9_3_1","unstructured":"Nederlandse Vereniging van Hemofiliebehandelaars (NVHB).Richtlijn Diagnostiek en behandeling van hemofilie 2020. Secretariaat p\/a Universitair Medisch Centrum Utrecht. Postbus 85500 3508 GA Utrecht."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.2011.01328.x"},{"key":"e_1_2_9_5_1","first-page":"77","article-title":"Bleeding disorders of importance in dental care and related patient management","volume":"73","author":"Gupta A","year":"2007","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_9_6_1","first-page":"20","article-title":"The expressed dental needs of patients attending a Haemophilia Reference Centre","volume":"1","author":"Fiske J","year":"2000","journal-title":"J Disabil Oral Health"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02716.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","unstructured":"SchafferR.Access to dental care for people with bleeding disorders: survey results of hemophilia treatment centers in the U.S. Special Care Dentist 2016.","DOI":"10.1111\/scd.12189"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"4","article-title":"The oral health of individuals with haemophilia: a review of the literature","volume":"107","author":"Hitchings EJ","year":"2011","journal-title":"N Z Dent J"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263X.1997.00231.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-263x.1999.00112.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2516.2001.00536.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2007.01440.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12002"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12325"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12657"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.17225\/jhp00081"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01919.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12324"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13678"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4274\/jpr.80037"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_413_20"},{"key":"e_1_2_9_23_1","first-page":"1","article-title":"Oral hygiene and dentist status in patients with hemorrhagic disorders: a comparative study","volume":"20","author":"Kumar M","year":"2020","journal-title":"Odontopediatric Clin Integr"},{"key":"e_1_2_9_24_1","unstructured":"World Health Organization.World Health: the magazine of the World Health Organization. World Health.1980."},{"key":"e_1_2_9_25_1","first-page":"3","article-title":"Development and evaluation of the oral health impact profile","volume":"11","author":"Slade GD","year":"1994","journal-title":"Community Dent Health"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01495.x"},{"key":"e_1_2_9_27_1","unstructured":"De VochtA Basishandboek SPSS 21. SPSS Statistics. Uitgever Bijleveld.2013."},{"key":"e_1_2_9_28_1","unstructured":"International Standard Classification of Education.Unesco Institute for Stastistics.2012."},{"key":"e_1_2_9_29_1","volume-title":"Gebit Fit? Een onderzoek naar de mondgezondheid en het tandheelkundig preventief gedrag van volwassenen in Nederland in 2013","author":"Schuller A","year":"2013"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13122"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-8-11"},{"key":"e_1_2_9_32_1","unstructured":"Nederlandse vereniging voor mondgezondheid (Ivoren Kruis). Richtlijn mondzorg voor jeugdigen1994."},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2014.08.002"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/idj.12113"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11482-009-9081-y"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.5177\/ntvt.2011.03.10221"}],"container-title":["Haemophilia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/hae.14719","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/hae.14719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T11:58:02Z","timestamp":1699012682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/hae.14719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,10]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/hae.14719"],"URL":"https:\/\/doi.org\/10.1111\/hae.14719","archive":["Portico"],"relation":{},"ISSN":["1351-8216","1365-2516"],"issn-type":[{"value":"1351-8216","type":"print"},{"value":"1365-2516","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,10]]},"assertion":[{"value":"2022-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}