{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T22:16:19Z","timestamp":1789251379295,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We assessed sociodemographic and clinical characteristics associated with depression and anxiety in individuals with Von Willebrand disease (VWD) aged \u226512\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study collected data on patients\u2019 sociodemographic, joint problems and health\u2010related quality of life (HRQoL) using EQ\u20105D\u20103L, 8\u2010item patient health questionnaire for depression and 7\u2010item Generalized Anxiety Disorder Questionnaire from participants in seven geographically diverse US haemophilia treatment centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses included 77 participants. The rates of depression and anxiety were 63.6% and 58.3%, respectively. Persons with low VWF displayed higher rates of depression (86.7%) or anxiety (69.2%) compared to those with VWD (58.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04 for depression, and 55.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.38 for anxiety). Logistic regression analyses demonstrated that having joint problems (odds ratio [OR]\u00a0=\u00a06.3, confidence interval [CI]\u00a0=\u00a02.0\u201320.1) was the most important variable associated with depression, followed by being single, divorced, widowed, or separated in adult participants or parents of participants age\u00a0&lt;\u00a018 years (OR\u00a0=\u00a07.0, CI\u00a0=\u00a01.7\u201329.0. The most important variable associated with anxiety was being single or lacking a partner (OR\u00a0=\u00a010.8, CI\u00a0=\u00a02.5\u201347.5), followed by age 12\u201317\u00a0years old (OR\u00a0=\u00a06.7, CI\u00a0=\u00a01.6\u201326.9), or having worse health compared to 3\u2010months ago (OR\u00a0=\u00a012.3, CI\u00a0=\u00a01.3\u2010116.2). Mean covariates adjusted EQ visual analogue scale score was significantly lower among persons with depression (68.77\u00a0\u00b1\u00a03.15 vs. 77.58\u00a0\u00b1\u00a04.24, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.03) than those without depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study revealed concerning levels of depression and anxiety in this VWD sample. Lack of social support was determined an important factor associated with depression and anxiety in this sample. Mental health screening is critical in VWD clinical evaluation and care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14725","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T19:50:22Z","timestamp":1671047422000},"page":"545-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Depression and anxiety in persons with Von Willebrand disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9415-9543","authenticated-orcid":false,"given":"Jonathan C.","family":"Roberts","sequence":"first","affiliation":[{"name":"Bleeding &amp; Clotting Disorders Institute  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9372-3184","authenticated-orcid":false,"given":"Roshni","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Michigan State University Center for Bleeding and Clotting Disorders  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3857-8313","authenticated-orcid":false,"given":"Peter A.","family":"Kouides","sequence":"additional","affiliation":[{"name":"Mary M. 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