{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T01:21:33Z","timestamp":1775438493008,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Haemophilia"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haemophilic arthropathy is one of the main causes of morbidity in people with haemophilia (PWH), inducing pain and reduced functionality. Therefore, PWH are complex patients and must be approached from a multidisciplinary perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effectiveness of a therapeutic exercise and cognitive\u2010behavioural therapy (CBT) combined protocol on functionality, pain, and joint health of PWH, arthropathy and chronic pain. Treatment satisfaction was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010blinded clinical trial with 21 PWH in prophylactic regimen was carried out. Participants were divided into an experimental group (EG, <jats:italic>n<\/jats:italic>\u00a0=\u00a011) and a control group (CG, <jats:italic>n<\/jats:italic>\u00a0=\u00a010). The EG underwent a 4\u2010month programme of home\u2010based therapeutic exercise plus CBT, whilst CG performed their daily activities. Patients were evaluated at baseline, post\u2010intervention and after 12 additional weeks. Measures of functionality (Haemophilia Activities List, Timed Up and Go Test, 2\u2010Minutes\u2010Walking\u2010Test and Sit\u2010to\u2010Stand Test), pain (PainDETECT and Visual Analogue Scale) and joint health (Haemophilia Joint Health Score) were taken. Related dimensions of the A36 Haemophilia Quality of Life Questionnaire were calculated. Effects were calculated using a two\u2010factor ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EG showed significant improvements in function (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), pain (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), joint damage (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006), and satisfaction with the treatment (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.006) dimensions of the A36 Haemophilia Quality of Life Questionnaire, as well as in pain measured with the Visual Analogue Scale (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) and PainDETECT (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined physiotherapy and CBT protocol showed a partial improvement in functionality, pain and joint health of PWH, arthropathy and chronic pain. In addition, participants were satisfied with the treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/hae.14735","type":"journal-article","created":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T18:34:25Z","timestamp":1672079665000},"page":"629-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effectiveness of therapeutic exercise and cognitive\u2010behavioural therapy combined protocol on functionality, pain and joint health in people with haemophilia: Secondary analysis of a controlled trial"],"prefix":"10.1111","volume":"29","author":[{"given":"Noem\u00ed","family":"Moreno\u2010Segura","sequence":"first","affiliation":[{"name":"Department of Physiotherapy University of Valencia  Valencia 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